This $705,915 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) aims to (1) determine the association between equol-producing status and atherosclerotic cardiovascular disease (ASCVD), and (2) develop integrative models of ASCVD incorporating equol, marine omega-3 fatty acids, metabolites, and other factors using probabilistic graphical models.
The research will leverage datasets from two case-control studies of ASCVD nested within the Tsuruoka Metabolomics Cohort Study and the Tohoku Medical Megabank Project in Japan. The award includes a $146,431 sub-grant to the University of Florida to support specific aspects of the project. The overall study has the potential to provide insights into the biological mechanisms underlying the cardiovascular benefits of the Japanese diet, with implications for ASCVD prevention in the U.S.
Generated 3/4/25, 6:07 AM