The National Heart, Lung, and Blood Institute (NHLBI) awarded a $498,991.40 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to the University of Arkansas. The grant, with a period of performance from January 2, 2025 to December 31, 2027, will support research to develop microphysiological systems that can precisely control oxygen levels to investigate the molecular pathways and functional effects of hypoxic injury on cardiomyocytes. The research aims to obtain a...
This $136,350 federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) supports research to investigate the role of arterial baroreceptors in the development of hypertension. The research aims to leverage novel approaches to selectively target and interrogate sensory neurons innervating the aortic arch in mice in order to understand how chronic elevations in blood pressure may disrupt the expression of...
This $635,224 federal Project Grant award was provided by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) to the University of California, Davis. The grant supports research to investigate the role of the cardiac microvasculature, myocyte ATP dynamics, and stochastic resonance in regulating sinoatrial node pacemaking activity, with a focus on understanding how changes in these factors contribute to alterations in cardiac...
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research (CFDA 93.837) program, will support research aimed at understanding the mechanically-sensitive signaling axis involving PANX1 and PIEZO1 channels in juxtaglomerular (JG) cells, and how this may regulate renin release - a key step in the renin-angiotensin-aldosterone system (RAAS) that controls blood pressure. The research team at the University of Virginia will...
This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), is focused on investigating the role of connexin hemichannels in the endothelium of resistance arteries and their impact on blood pressure regulation. The primary objectives are to: 1) determine if the TRPV4/CX43 hemichannel signaling node is a key component in arteriolar dilation, and 2) assess if hypertensive mouse models exhibit...
This $385,191 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports research to study the structure, function, and regulation of ATP-sensitive potassium (KATP) channels. The project, conducted by The Trustees of Trinity College, a private non-profit university in Hartford, Connecticut, aims to develop novel spectroscopic tools to simultaneously probe KATP channel dynamics and function. Key...
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), supports research to investigate the role of potassium ion channels in regulating the excitability of vagal visceral nociceptors. The $458,767 award to The Johns Hopkins University aims to elucidate the ionic and molecular mechanisms underlying visceral nociceptor sensitization, with the goal of identifying new therapeutic strategies to manage...
This $644,687 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) supports research to investigate a neural circuit comprised of orexin neurons, corticotropin-releasing hormone neurons in the hypothalamus, and neurons in the nucleus of the solitary tract. The research aims to determine how this circuit facilitates the peripheral chemoreflex and contributes to the hypertension that follows chronic...
The Project Grant award K99HL177340, provided by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research Federal Grant Program (CFDA 93.837), aims to identify novel contextual and genomic blood pressure (BP) measures to enhance cardiovascular disease (CVD) prediction and management in young adults aged 18-39 years. The $165,364 award, with a project period from February 1, 2025 to January 31, 2027, will support research led by Dr. Cho, a cardiovascular...
This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), with CFDA program title "Cardiovascular Diseases Research" (93.837), supports research focused on understanding the role of the voltage-gated proton channel HV1 in the development of pulmonary hypertension. The $522,794 award, with a period of performance from June 1, 2025 to March 31, 2029, will enable the University of Illinois to apply transgenic mouse models and complementary in vivo...