Project Grant K01DK142040
- This federal Project Grant award of $133,328 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research at The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH), to dissect the roles of the PPM1D and TP53 genes in hematopoietic stem cells and clonal hematopoiesis. The research aims to understand how mutations in these genes...
- This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $465,155 to Brigham & Women's Hospital Inc. to conduct research on the role of the SRCAP gene in therapy-related clonal hematopoiesis and the development of therapy-related myeloid neoplasms. The award supports the development of a novel conditional mouse model to study the impact...
- This Project Grant award, valued at $801,000.00, was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The funding supports research at The Children's Hospital Corporation, doing business as Boston Children's Hospital, to investigate the role of stress granules in red blood cell development, particularly during stress conditions. The research aims to uncover the...
- The National Institute on Aging (NIA), part of the U.S. Department of Health and Human Services, awarded a $132,705 Project Grant under the Aging Research program (CFDA 93.866) to The Children's Hospital Corporation (doing business as Boston Children's Hospital). The award aims to conduct research on "Targeting Metabolic Vulnerabilities to Restore Balanced Hematopoiesis During Aging," with a project period from June 15, 2025 to May 31, 2027. The research will use single-cell...
- This Project Grant award of $125,532.00, provided by the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research), aims to investigate the disruption of the clonal architecture of human hematopoietic stem cells driven by high-effect somatic and germline genetic variants, and identify the resulting phenotypic changes that lead to impaired stem cell function and increased disease risk with aging. The research will utilize a mitochondrial lineage tracing...
- This Project Grant award of $126,830 from the National Human Genome Research Institute (CFDA 93.172 - Human Genome Research) supports a research project titled "Deciphering Determinants of Somatic Evolution with Single-Cell Genealogy." The project aims to develop a somatic mutation-resolved lineage tracing system that reconstructs single-cell genealogical trees and jointly detects somatic mutations and epigenetic alterations. This system will be used to study the evolutionary...
- This federal Project Grant award of $560,100 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), aims to elucidate how environmental exposures, such as industrial pollution and catastrophic events, lead to hematopoietic stem cell dysfunction and the progression of clonal hematopoiesis. The project, awarded to the Albert Einstein College of Medicine in Bronx, NY, will...
- This $133,315 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) supports research conducted by the University of Rochester to investigate the impact of bone turnover and local inflammatory profiles on the expansion of clonal hematopoiesis (CH) in live animal models. The project aims to establish a robust methodology for tracking CH clones and skeletal dynamics through...
- The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded Vanderbilt University Medical Center (VUMC) a $150,000 Project Grant under CFDA 93.847, the Diabetes, Digestive, and Kidney Diseases Extramural Research program. The grant, which runs from Sep 1, 2023 to Aug 31, 2024, will fund a study to identify factors that contribute to clonal expansion and disease progression in clonal hematopoiesis of indeterminate potential (CHIP). The research aims to dissect the...
- This Project Grant award from the National Institutes of Health (NIH) Trans-NIH Research Support program (CFDA 93.310) provides $388,749 to The Washington University in Missouri to conduct research focused on understanding the impact of clonal hematopoiesis on the aging human bone marrow. The goal is to investigate how these somatic mutations that can drive leukemia exist and interact within the bone marrow niche in cancer-free adults, which may yield insights into how these pre-malignant states...
This federal Project Grant award of $154,860 from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847) supports research on the mechanisms of clonal competition in age-related clonal hematopoiesis. The grant, awarded to The Children's Hospital Corporation (Boston Children's Hospital), aims to investigate factors that drive the expansion of "super-competitor" clones bearing DNMT3A mutations, which are associated with increased risk of hematologic diseases in older adults. The research will validate the role of the gene SLC3A2 in regulating DNMT3A mutant cell expansion, both in vitro and in vivo. The study period runs from August 1, 2025 to May 31, 2028 and is expected to yield insights into the molecular mechanisms underlying clonal competition in age-related hematopoietic disorders.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $154.9k | 8/1/25 |