This Project Grant award of $147,400 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), supports research to investigate how antigen non-related CD4+ T cells contribute to the pathogenesis of skin fibrosis in systemic sclerosis (scleroderma) and sclerodermoid graft-versus-host disease. The project aims to characterize bystander activation of CD4+ T cells in a mouse model of...
This $100,000 Project Grant award from the National Institutes of Health (NIH) Trans-NIH Research Support program (CFDA 93.310) aims to investigate the role of immune and inflammatory cells in driving the pathological fibrosis seen in systemic sclerosis-associated interstitial lung disease (SSc-ILD). The University of Pittsburgh will refine explant culture methodologies to examine the effect of key cytokines, such as TGF-beta, PDGF, IL-6, and IL-13, on healthy control and SSc-ILD lung cells....
This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), will provide $401,433 from September 2023 to August 2025 to support research at the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University. The research aims to investigate the role of protein O-GlcNAcylation in regulating keratinocyte function and its impact on skin...
This federal Project Grant award, valued at $550,909.00, was provided by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The award supports comprehensive research into the causes, treatment, and prevention of arthritis, musculoskeletal disorders, and skin diseases, with a specific focus on understanding the intrinsic and extrinsic factors regulating the competition for...
This federal Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) provides $613,036 to Fibrobiologics LLC to develop a novel peptide-based therapeutic agent called M10 for treating skin fibrosis associated with systemic sclerosis (scleroderma). The project aims to determine the antifibrotic activity of M10 in primary skin fibroblasts from scleroderma...
This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), provides $173,719 to Trustees of Boston University (Boston University Medical Campus) to prospectively evaluate the use of Spatial Frequency Domain Imaging (SFDI) as an objective and sensitive measure for tracking skin changes over time in patients with systemic sclerosis (scleroderma). The research...
This federal Project Grant award, totaling $242,310, was provided by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The grant supports research at Rockefeller University to investigate the long-term systemic consequences of type 2 skin inflammation on epithelial stem cells. Specifically, the research aims to define the cellular mechanisms that distinguish inflammatory...
The National Institutes of Health's National Institute of Arthritis and Musculoskeletal and Skin Diseases awarded New York University School of Medicine $409,311.92 under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) from April 5, 2021 to January 25, 2022. The project grant funding supports research into the role of T follicular helper (TFH) cells in the pathogenesis of dermatomyositis, a severe inflammatory myopathy. Specifically, the award will fund studies to...
The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a $306,324 Project Grant (CFDA 93.846 - Arthritis, Musculoskeletal and Skin Diseases Research) to the Oklahoma Medical Research Foundation (OMRF) for the project "Deciphering the Myofibroblast Life Cycle in Skin Wound Healing". The grant, with a period of performance from September 1, 2024 to March 31, 2027, will fund research to create a molecular map of the myofibroblast life cycle and...
This $497,083 Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) supports research to elucidate the genetic and molecular basis of scarless, multi-lineage skin regeneration in fetal mice. The project aims to create comprehensive cellular and molecular atlases of fetal versus postnatal wound healing processes using single-cell multiomics approaches. The...