This Project Grant award in the amount of $147,400 was provided by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The funding will support research by Yale University to investigate how antigen-independent activation of CD4+ T cells regulates skin fibrosis in scleroderma and sclerodermatous graft-versus-host disease. The research aims to characterize the role of...
This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), will provide $401,433 from September 2023 to August 2025 to support research at the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University. The research aims to investigate the role of protein O-GlcNAcylation in regulating keratinocyte function and its impact on skin...
The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a $613,036 Project Grant (CFDA 93.846 - Arthritis, Musculoskeletal and Skin Diseases Research) to Fibrobiologics LLC to develop a novel therapeutic agent, M10, for treating skin fibrosis associated with systemic sclerosis (scleroderma). The award supports research activities to determine the antifibrotic activity of M10 in primary skin fibroblasts from scleroderma patients and evaluate its efficacy in...
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), will provide $173,216 to Yale University to conduct research on evaluating digital ischemia in patients with systemic sclerosis (scleroderma) using multiparametric MRI. The key objectives are to: 1) test quantitative MRI biomarkers to complement clinical assessments of vasculopathy, ischemia, and fibrosis, and 2) determine if short-term changes...
This $493,905 Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) will support research by the Benaroya Research Institute at Virginia Mason (BRI) to investigate the role of T cells in regulating dermal fibroblast gene programs and dysfunction in systemic sclerosis (scleroderma).
The award will enable BRI researchers to use single-cell spatial transcriptomics and organotypic skin culture models to study...
This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) provides $176,148 to The Regents of the University of California, San Francisco (UCSF) to conduct research on the role of PI16-expressing fibroblasts in mouse and human fibrosing skin disease. The 5-year research project aims to elucidate how this specific fibroblast subset responds to and...
This $706,710 Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) will fund research at Virginia Commonwealth University (VCU) to investigate the role of sphingolipid biosynthesis in the epidermal barrier for healthy and diseased skin. The research aims to understand how unique sphingoid backbones generated by the serine palmitoyltransferase (SPT) enzyme...
The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a $194,700 Project Grant under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) to Boston Children's Hospital. The grant, running from Sep 1, 2024 to Aug 31, 2026, will support research to characterize the neurobiological basis and behavioral outcomes of cognitive dysfunction in children with childhood-onset systemic lupus erythematosus (cSLE). The research will utilize...
This $788,508 Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) supports research into the regulatory mechanisms linking Langerhans cells and lymphatic function in systemic lupus erythematosus (SLE). The award recipient, The Hospital for Special Surgery Fund, Inc. (doing business as HSS Foundation), will conduct this 5-year research project to investigate how...
This $119,986 project grant awarded by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) supports research to identify epigenetic factors regulating the antifibrotic transcription factor KLF4 in systemic sclerosis-associated lung fibrosis.
The primary objectives are to: 1) Determine the involvement of histone deacetylases in the transcriptional repression of KLF4 in pulmonary...