This Project Grant award, valued at $499,746.00, was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under CFDA Program 93.855 - Allergy and Infectious Diseases Research. The award supports research to uncover the genetic basis and molecular mechanisms underlying the propensity of T cells towards autoimmunity. Key focus areas include: Elucidating the role of mitochondrial cristae integrity and oxidative stress in regulating effector T cell functions and...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 Allergy and Infectious Diseases Research) provides $185,509.00 to Texas A&M University System Health Science Center to conduct research on reducing lung immunopathology in a mouse model of mitochondrial disease. The key objectives are to: 1) Test the hypothesis that elevated type I interferon signaling and reduced NRF2 activity in POLG mutant macrophages promotes hyperinflammatory innate...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to investigate the mechanistic impact of a genetic variant associated with Parkinson's disease on immune system function and susceptibility to infection. The $162,000 award to The Administrators of Tulane Educational Fund (Tulane University) will fund experiments to uncover how the LRRK2-G2019S mutation...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, aims to develop a new therapy for neurodevelopmental mitochondrial disorders. The $105,625 award to the Icahn School of Medicine at Mount Sinai, from August 1, 2024 to July 31, 2026, will support two main objectives: 1) analyzing how a specific succinyl-CoA precursor is...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $797,735 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the Icahn School of Medicine at Mount Sinai. The grant aims to elucidate the innate and adaptive immune mechanisms governing neonatal responses to allergens, with the goal of developing targeted therapeutics and preventive strategies against early-life inflammation. The research project will utilize a novel mouse model to...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $516,175 Project Grant under CFDA 93.855, Allergy and Infectious Diseases Research, to Seattle Children's Hospital/Seattle Children's Research Institute. The grant, effective June 23, 2025 through May 31, 2027, will fund research to evaluate the impact of pre-existing humoral immunity on hepatocyte death in the context of malaria infection. The research aims to understand how non-neutralizing antibodies that bind...
The federal Project Grant award of $857,346.00, awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research at the Fred Hutchinson Cancer Center in Seattle, Washington. The goal is to study the balance of activating and inhibitory signals, in the form of cytokines and metabolites, that regulate the effector function of CD8 T cells in healthy and infected human tissues. The research aims...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) supports research on the regulation of mitophagy and inflammation by the protein ZFAND6. The $707,534 award to Pennsylvania State University, Milton S. Hershey Medical Center will fund a 5-year study investigating the mechanisms by which ZFAND6 regulates mitophagy, inflammation, and the NLRP3 inflammasome. The research aims to provide new...
This Project Grant award of $3,087,416.00 from the National Institute on Aging (NIA), under the Aging Research program (CFDA 93.866), supports research to elucidate the mechanism by which the DELE1 protein activates the HRI kinase to relay mitochondrial stress to the Integrated Stress Response (ISR) pathway. The research aims to provide a comprehensive, mechanistic description of the key interactions between DELE1, HRI, and eIF2A that transduce mitochondrial stress to ISR activation. The award...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will provide $793,777 to the J. David Gladstone Institutes, a non-profit biomedical research organization in San Francisco, CA, to study the impact of mitochondrial genome architecture on the accumulation of somatic mitochondrial DNA (mtDNA) mutations over an individual's lifetime. The research aims to understand how mtDNA compaction influences mutation rates and mitochondrial health, with potential...