Project Grant R01AG089237

Award Date 9/15/24
Completion Date 8/31/29
Dollars Obligated $944K
Federal Grant Program
93.866
Assistance Type
Project Grant
Place of Performance
Boston, MA 02215, USA
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This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will fund a $811,443 cluster randomized trial to evaluate the impact of a shared decision-making (SDM) training program for breast surgeons and a patient decision aid for women aged 70+ with early-stage, low-risk breast cancer. The goal is to reduce the use of low-value treatments, such as mastectomy, sentinel lymph node biopsy, and radiation therapy after breast-conserving surgery, without...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $624,000.00 to the University of Texas Health Science Center at Houston to explore a patient priorities care framework for improving breast cancer survivorship care for older women with multiple chronic conditions. The project aims to use this framework to identify patient priorities, incorporate them into treatment plans, and evaluate the feasibility and impact on treatment burden and quality...
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This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $388,750 to The Washington University to conduct research on the role of senescent cancer-associated fibroblasts (senCAFs) in breast cancer progression. The key objectives are to: 1) Determine the organ-specific effects of senCAFs on metastatic breast cancer progression; 2) Examine how senCAFs impact extracellular matrix dynamics and tumor cell migration; and 3) Assess the impact of senCAFs on...
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The federal Project Grant award R01AG089237, funded by the National Institute on Aging's Aging Research program (CFDA 93.866), aims to determine the effectiveness of a shared decision-making (SDM) toolkit in decreasing surveillance mammography use among breast cancer survivors aged 80 and older. The total award amount is $943,540.00 over the project period from Sep 15, 2024 to Aug 31, 2029. The award recipient is the Dana-Farber Cancer Institute, Inc. (DFCI), a non-profit hospital and cancer research center in Boston, MA. DFCI is collaborating with sub-awardees Mayo Clinic, Beth Israel Deaconess Medical Center, and the University of Rochester to execute the study, which involves recruiting participants, delivering the SDM intervention, and measuring outcomes related to mammography use, decision quality, and knowledge. The project seeks to accelerate the development and implementation of tailored breast cancer survivorship guidelines for older individuals.

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