This federal Project Grant award from the National Institute on Aging (Aging Research, CFDA 93.866) provides $4,027,679 to Boston University Medical Campus (Trustees of Boston University) to develop a digital cognitive health resource based on the Boston University Alzheimer's Disease Research Center (BU ADRC) cohort. The project aims to collect longitudinal digital cognitive metrics, assess their relationship with vascular risk factors and neuroanatomic measures, and build machine learning...
This Project Grant award, valued at $134,730.00, was issued by the National Institute on Aging (NIA), under the Aging Research federal grant program (CFDA 93.866), to The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH). The goal of this project is to develop electroencephalogram (EEG) biomarkers to predict the future risk of dementia and monitor cognitive decline in older adults. The research will leverage existing datasets from the National Sleep Research...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will fund research to improve understanding of digital cognitive markers for diagnosing and predicting cognitive health in Alzheimer's disease. The $441,612 award to Trustees of Boston University will support three key objectives: Comparing cross-sectional and longitudinal associations between the Life's Essential 8 (LE8) metrics and digital cognitive measures versus conventional neuropsychological...
This $287,118 Project Grant was awarded on September 1, 2023 by the National Institute on Aging (NIA) under the Aging Research (CFDA 93.866) grant program. The grant will fund the development of techniques to use deep transfer learning and multimodal data, including brain MRIs, genetic information, and cognitive tests, to enable the early detection and forecasting of Alzheimer's disease progression. The University of Massachusetts (UMass), as the prime awardee, will create an end-to-end...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to Emory University will develop explainable and ethical artificial intelligence (AI) models to assist in the diagnosis and prognosis of Alzheimer's disease (AD). The $738,014 award, running from August 2024 to April 2029, will leverage multimodal data fusion and cerebrospinal fluid proteomics to enhance understanding of AD pathophysiology. The goal is to create improved and ethical AI-based clinical...
This $107,948 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to enhance understanding of the biological signatures that distinguish subgroups of patients with Alzheimer's disease (AD). The key goals are to: Determine if AD subtypes can be identified solely using magnetic resonance imaging (MRI)-derived features through the application of machine learning algorithms. Integrate epigenetic profiles, including small non-coding RNA expression and DNA...
This Project Grant award from the National Institute on Aging's Aging Research Federal Grant Program (CFDA 93.866) provides $817,357 to the J. David Gladstone Institutes, a non-profit biomedical research organization, to develop and validate advanced machine learning (ML) approaches for comprehensive behavioral phenotyping and brain signal integration in humanized Alzheimer's disease (AD) mouse models. The key goals are to: 1) further validate the Variational Animal Motion Embedding (VAME) ML...
This Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) provides $885,006 to Brigham & Women's Hospital Inc. to develop a smartphone-based point-of-care diagnostic system for detecting Alzheimer's disease-related biomarkers in blood plasma. The system will utilize microfluidics, nanotechnology, optical sensing, and deep learning to measure amyloid-beta, phosphorylated tau, and neurofilament light chain within 30 minutes, with the goal of creating an...
This federal Project Grant award of $307,000.00 from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to conduct a single, highly powered study to identify memory processes that are most sensitive to the asymptomatic, preclinical stage of Alzheimer's disease (AD) pathology. The study combines a continuous report item-location associative memory task with advanced behavioral and neural modeling to estimate subtle changes in memory precision that may differentiate healthy...
This federal Project Grant award of $802,034 from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) will fund a multimodal, multiscale, and multistage systems biology (M3SB) infrastructure to advance precision medicine for Alzheimer's disease (AD) and longevity. The project aims to: 1) conduct multi-omic analyses to identify bioage-modifying targets and repurposable medicines for AD/ADRD; 2) build inflammatory aging (iAge) and phenoAge clocks using longitudinal...