This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to the Trustees of Boston University, doing business as Boston University Medical Campus, provides $2,330,859.00 in funding to study age-related changes in brain network connectivity and their relationship to cognitive decline. The 3-year project aims to use multimodal neuroimaging, single-cell transcriptomics, electrophysiology, and neural tract-tracing in a rhesus monkey model to delineate how...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $466,125 to New York University (NYU) to develop a biologically relevant multi-scale model of brain aging using advanced diffusion MRI (dMRI) techniques. The project aims to generate brain charts of quantitative dMRI and mesoscopic MRI (mesoMRI) markers across the lifespan, creating a brain microstructure age framework. This framework will then be used to evaluate the effects of...
The National Institute on Aging (NIA), part of the Department of Health and Human Services National Institutes of Health, awarded a $3.37 million Project Grant to The University of Texas at Arlington to develop an individualized deep connectome framework for Alzheimer's disease and related dementias (ADRD) analysis. The three-year grant, awarded on August 18, 2022 under the NIA's Aging Research program (CFDA 93.866), will support research to discover and identify individualized...
This Project Grant award of $1,541,942.00 from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) supports the development of flexible multivariate models for linking multi-scale brain connectome and genomic data in Alzheimer's disease and related disorders. The research aims to create advanced algorithmic approaches that can perform joint decomposition of multimodal neuroimaging and genomic data, addressing key limitations of existing data fusion models. The...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will fund a study to examine how high-resolution diffusion imaging can provide new insights into age-related changes in white matter connectivity and their impact on cognitive function and brain network dynamics. The $300,892 award to Duke University, which runs from October 2024 through April 2027, will support research across three aims: 1) comparing standard and high-resolution diffusion imaging...
The National Institute on Aging (NIA) awarded a $137,895 Project Grant under the Aging Research federal grant program (CFDA 93.866) to the University of California, Berkeley (UC Berkeley) with a project period from December 3, 2024 to July 31, 2027. The grant will fund a study to investigate how brain network connectivity is associated with Alzheimer's disease (AD) risk, longitudinal pathology accumulation, and aging. Specifically, the project will use positron emission tomography (PET)...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will provide $203,278 to Brandeis University from November 2024 to January 2026 to conduct research on the neurobiological mechanisms underlying daily life activity participation in older adults and its relationship to Alzheimer's disease pathology. The project will use a multilevel, multimodal framework including behavioral, psychophysiological, neuroimaging, and naturalistic approaches to understand...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $636,342 to Trustees of Boston University's Boston University Medical Campus to conduct multiscale modeling and empirical studies of normal and pathological brain aging. The research aims to elucidate the relationships between myelin dystrophy, synaptic loss, and neuronal hyperexcitability in the dorsolateral prefrontal cortex, and how these changes contribute to age- and Alzheimer's...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) for $385,612 aims to integrate experimental and computational models to study prefrontal microcircuit changes during healthy aging and Alzheimer's disease progression. The research team at the University of Wyoming will use in vivo calcium imaging, computational simulation modeling, and neural decoding to directly visualize and predict microcircuit changes in the prefrontal cortex. A sub-award of an...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will support Emory University's research into the genetic regulation of brain transcriptomics and proteomics associated with Alzheimer's disease and related dementias. The $528,876 award, effective June 1, 2025, will fund the development of new analytic tools to integrate genomic data across multiple tissues and improve the identification of genetic risk factors and underlying molecular mechanisms for...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $514,216 to Texas A&M University to conduct research on brain connectomics and their relationship to cognitive aging and Alzheimer's disease vulnerability. The key research goals are to: 1) Examine how changes in brain functional and structural connectivity measures (connectomes) are associated with changes in cognitive performance over time, serving as potential biomarkers of cognitive aging; 2) Investigate whether connectome changes correlate with Alzheimer's-related pathologies measured via PET and plasma; and 3) Evaluate how socioeconomic status may modulate the relationships between brain connectomes, cognition, and Alzheimer's risk. This 5-year award aims to enable the principal investigator to develop an independent aging research program integrating neuroimaging, cognitive, and biological assessments, with the long-term objective of improving risk prediction and interventions for Alzheimer's disease.