This Project Grant award of $510,412.27 from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273) will fund research to investigate the role of the gut microbiota in alcohol seeking and reward-related decision-making. The research will use mouse models and computational modeling to determine if manipulating the gut microbiota, such as through the use of prebiotics, can mitigate alcohol-induced behavioral impairments. The award period...
This federal Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA), under the Alcohol Research Programs (CFDA 93.273) federal grant program, will support the development of novel 3D human brain circuits to investigate the role of microglia in alcohol use disorder (AUD) and Alzheimer's disease (AD) pathology. The $223,531 award to the University of North Carolina at Chapel Hill will fund research to elucidate how alcohol-induced changes in microglial metabolism...
This federal Project Grant award, totaling $691,521.68, was provided by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273) to The Medical University of South Carolina. The goal of the research is to characterize how binge alcohol drinking alters the translational and physiological landscape of serotonin receptor-containing neurons in the lateral habenula that project to the dorsal raphe nucleus, and to investigate the functional...
This Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA), under the Alcohol Research Programs (CFDA 93.273) federal grant program, will support the development and testing of a novel in vivo model called CHIMERA-BONCAT. This model will enable comprehensive, unbiased, and cell-type-specific characterization of the human microglial response to alcohol exposure. The $214,385 award, with a period of performance from August 2024 to July 2026, will fund research...
The National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded a $736,668 Project Grant under the Alcohol Research Programs (CFDA 93.273) to the University of Southern California to conduct a multi-method investigation of social facilitation of alcohol effects and alcohol misuse in young adults. The project aims to extend prior research on the phenomenon of social facilitation of alcohol effects, exploring predisposing factors and mechanisms. This will involve laboratory-based studies...
The National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded a $194,551 Project Grant under the Alcohol Research Programs (CFDA 93.273) to The Medical University of South Carolina. The funding supports research to investigate the effects of adolescent intermittent ethanol exposure on the regulation of a neural pathway involving the prelimbic cortex and ventrolateral periaqueductal gray, and its impact on pain processing and sensitivity. The research aims to elucidate how changes in the...
The National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded a Project Grant under the Alcohol Research Programs (CFDA 93.273) to the University of Illinois. The $293,128 grant, awarded on August 23, 2024, will fund a study examining the neural correlates of alcohol reward in social contexts using a hyperscanning EEG setup. The research aims to evaluate the neural mechanisms underlying the rewarding effects of alcohol in social settings and assess how individual and group-level factors...
This Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA), under the Alcohol Research Programs (CFDA 93.273), provides $249,000.00 to the University of North Carolina at Wilmington to investigate how adolescent binge drinking impacts the integration of newborn neurons into mature hippocampal circuitry. The research aims to elucidate the cellular and physiological mechanisms by which adolescent alcohol exposure disrupts the maturation and circuit integration...
The National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded a $537,587 Project Grant under the Alcohol Research Programs (CFDA 93.273) to The University of Texas Southwestern Medical Center to conduct research on the metabolic consequences of liver inflammation on alcohol consumption and alcohol-associated liver disease (ALD). The key objectives are to identify the mechanisms by which the transcription factor IRF3 suppresses the expression and secretion of the metabolic regulator...
This $499,987 Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273) will fund the development of a High Throughput Alcohol Screening Platform (HT-ASP) that incorporates cortical organoids. The project aims to create an automated platform to mature, maintain, and assay over 100 organoids in culture, providing a robust and genetically diverse system for screening potential alcohol use disorder therapeutics. The...