Project Grant HT9425261E043
- Federal Grant Award Summary The University of Texas MD Anderson Cancer Center received a $490,500 Project Grant award from the Defense Health Agency under the Military Medical Research and Development program (CFDA 12.420), effective September 1, 2025, through August 31, 2028. The grant funds research combining TROP2-directed chimeric antigen receptor natural killer (CAR-NK) cells with HIF2A (hypoxia-inducible factor 2-alpha) inhibition to develop novel immunotherapy approaches for pancreatic...
- Federal Grant Award Summary The University of Texas MD Anderson Cancer Center received a $349,996 Project Grant from the Defense Health Agency (DHA) under the Military Medical Research and Development program (CFDA 12.420) for the project "Metabolic Rewiring of CAR-T Cells to Counter the Hostile Tumor Microenvironment in Ovarian Cancer." The award was obligated on June 15, 2026, with a completion date of June 14, 2028. This research initiative focuses on developing chimeric antigen...
- Federal Project Grant Award Summary The University of Texas MD Anderson Cancer Center received a $735,751 project grant from the Defense Health Agency (DHA) under the Military Medical Research and Development program (CFDA 12.420), effective September 1, 2025, through August 31, 2028. The award supports research and development activities focused on combining TROP2-directed chimeric antigen receptor natural killer (CAR-NK) cells with HIF2A (hypoxia-inducible factor 2-alpha) inhibition as an...
- Federal Project Grant Award Summary The University of Texas MD Anderson Cancer Center received a $1,099,986 Project Grant award from the Defense Health Agency (DHA) under the Military Medical Research and Development program (CFDA 12.420) on June 1, 2026. The award, which runs through May 31, 2030, supports research on "Metabolic Rewiring of CAR-T Cells to Counter the Hostile Tumor Microenvironment in Pancreatic Cancer." This project focuses on developing and optimizing chimeric...
- Federal Project Grant Award Summary The University of Texas MD Anderson Cancer Center received a $817,496 project grant from the Defense Health Agency (DHA) under the Military Medical Research and Development program (CFDA 12.420) effective September 1, 2025, through August 31, 2028. The award funds research to investigate the PRMT3-IGF2BP1 axis-mediated epitranscriptomic reprogramming as a novel therapeutic strategy to overcome immunotherapy resistance in clear cell renal cell carcinoma...
- Federal Project Grant Award Summary The Defense Health Agency (DHA) awarded The University of Texas MD Anderson Cancer Center a Project Grant of $893,525 under the Military Medical Research and Development program (CFDA 12.420) for the period September 1, 2025, through August 31, 2028. The project, titled "Targeting Neuronal Mimicry in SMARCB1-Deficient Renal Medullary Carcinoma Treatment," focuses on advancing therapeutic approaches for a rare kidney cancer by investigating how...
- Federal Grant Award Summary The University of Texas MD Anderson Cancer Center received a $1.35 million Project Grant from the Defense Health Agency (DHA) under the Military Medical Research and Development program (CFDA 12.420) for the three-year period from October 1, 2025, through September 30, 2028. The award funds research focused on building T-cell products for neurofibromatosis type 1 (NF1)-associated malignant peripheral nerve sheath tumors (MPNST) through antigen discovery and...
- Federal Project Grant Award Summary The University of Texas MD Anderson Cancer Center received a $414,472 Project Grant from the Defense Health Agency (DHA) under the Military Medical Research and Development program (CFDA 12.420) effective September 1, 2025, through August 31, 2028. The award supports research targeting neuronal mimicry in SMARCB1-deficient renal medullary carcinoma treatment. This three-year initiative represents DHA's investment in precision oncology research addressing...
- Federal Grant Award Summary The University of Texas MD Anderson Cancer Center received a $489,767 Project Grant from the Defense Health Agency (DHA) under the Military Medical Research and Development program (CFDA 12.420) effective October 1, 2025, through September 30, 2028. The award supports research titled "Building T-Cell Products in NF1-Associated MPNST Through Antigen Discovery and Epigenome Targeting," which addresses the development of therapeutic T-cell immunotherapy...
- Federal Grant Award Summary Award Details: The Defense Health Agency (DHA) awarded The University of Texas MD Anderson Cancer Center a $559,463 Project Grant under the Military Medical Research and Development program (CFDA 12.420) for the period August 1, 2026, through July 31, 2028. The project, titled "Alternating Clonal Dominance and Local Microenvironment Evolution at the Primary Tumor Site as Key Drivers of Metastatic Dissemination in Pancreatic Cancer," supports basic and...
Award Details:
The Defense Health Agency (DHA) awarded a $560K Project Grant to The University of Texas MD Anderson Cancer Center under the Military Medical Research and Development program (CFDA 12.420) for the period September 1, 2026 through August 31, 2028. The project, titled "Modulating Hypoxia-Activated Stromal Programs to Potentiate CAR-T Cell Therapy in Kidney Cancer," will be conducted in Houston, Texas. Project Scope:
This research initiative focuses on advancing chimeric antigen receptor T-cell (CAR-T) therapy for kidney cancer treatment through investigation of hypoxia-activated stromal programs. The grant supports investigator-initiated basic and applied biomedical research designed to develop enhanced immunotherapeutic approaches for cancer patients, consistent with the DHA's mission to improve medical outcomes for Service Members and the broader public. The two-year project will generate research findings, data, and potentially therapeutic insights that could inform the development and optimization of CAR-T cell-based treatments for renal cell carcinoma. MD Anderson Cancer Center, a National Cancer Institute-designated Comprehensive Cancer Center, serves as the prime recipient and will conduct the research with institutional expertise in translational oncology and cellular immunotherapy.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $560.0k | 3/26/26 |