Project Grant HT94252510402

This $3.5 million project grant from the National Institutes of Health's National Institute on Aging will fund research into sex differences related to epigenetic parent-of-origin effects and Alzheimer's disease. The Regents of the University of California, San Francisco will investigate how the maternal versus paternal X chromosome impacts neural vulnerability to Alzheimer's-related deficits in mouse models and primary neurons. The researchers hypothesize that imprinting or silencing of genes...

This Project Grant award of $305,000.00 from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to investigate the role of stem-like T cells in multiple sclerosis (MS) disease progression. The key objectives are to: Rigorously test the hypothesis that a continuing stemness and differentiation of CD4+ T stem cells results in functional and transcriptomic diversification under evolving...

This $1,559,700 Project Grant award from the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310) funds research by the Benaroya Research Institute at Virginia Mason (BRI) to investigate how genetic and epigenetic factors influence T cell function in autoimmune diseases. The key objectives are to: 1) use CRISPR-interference screening to identify regulatory regions that impact T cell proliferation and migration, 2) apply single-cell...

This five-year, $813,838 project grant from the National Institute of Allergy and Infectious Diseases will fund research into the genetic and hormonal mechanisms underlying sex differences in tuberculosis (TB) and TB-HIV coinfection. The Johns Hopkins University will investigate how X chromosome complement and sex steroid hormones impact TB pathogenesis using cellular models, animal studies, and human samples. Researchers will utilize a novel four core genotype mouse model to differentiate the...

This Project Grant award of $399,829.00, provided by the National Cancer Institute (CFDA 93.394 - Cancer Detection and Diagnosis Research), aims to develop novel glioblastoma (GBM) models to investigate the impact of sex chromosomes and sex hormones on GBM phenotype, including proliferation and cellular metabolism. The award will fund two key objectives: 1) Using the Four Core Genotypes mouse model, the researchers will define the contributions of sex chromosomes and in utero sex hormone...

This Project Grant award from the National Institute on Aging (NIA) under CFDA 93.866 - Aging Research supports a research study to determine how biological sex influences the self-renewal of B1 cells, a subset of B cells that produce natural antibodies, in aged mice and humans. The goal is to elucidate the mechanisms behind differential B1 cell self-renewal in aged males versus aged females, which could inform strategies to maintain healthy natural immunity into old age. The $1,526,780 award,...

This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855), provides $149,528 to The Johns Hopkins University to conduct research on the mechanisms underlying sex differences in vaccine-induced immunity. The research aims to investigate how estrogen receptor signaling and mTOR activation in B cells influence metabolic processes and contribute to greater antibody...

This federal Project Grant award from the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310) provides $550,812 to the University of California, Los Angeles (UCLA) to investigate the role of the KDM5C gene on the X chromosome in contributing to sex differences in adipose tissue function and risk of cardiovascular disease. The key objectives are to: 1) Determine if KDM5C gene dosage impacts weight/fat gain in hypogonadal states; 2)...

This Project Grant award from the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310) will provide $896,013 to the Regents of the University of Michigan over a 5-year period from September 2024 to August 2029. The funding will support research to define the origins and evolution of mammalian sex chromosome dosage compensation mechanisms, which equalize X-linked gene expression between XX females and XY males. The research aims...

This National Institutes of Health (NIH) Trans-NIH Research Support program award of $752,937 supports the "BUILD TO LEAD - BUILDING PARTNERSHIPS TO LINK THE EXPOSOME TO AUTOIMMUNE DISEASE (ADMIN SUPP)" project at the Benaroya Research Institute at Virginia Mason (BRI) from September 26, 2023 to August 31, 2025. The project aims to establish additional collaborations with experts in environmental exposures, expand the Autoimmune Exposome Summits, and harmonize exposome data...