The National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded a $207,170 Project Grant to Harvard Medical School to investigate sex differences in T cell metabolism. The research aims to assess sex differences in T cell function and metabolism, and explore the contribution of sex hormones versus sex chromosomes to these differences in the context of viral infection. The study will utilize techniques such as...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $112,956 to Texas A&M University System Health Science Center to study the integration of biological sex, immunity, and metabolism and its impact on infection susceptibility. The primary goals are to define the role of sex-specific traits in influencing energetic trade-offs that underlie innate immune responses,...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a 2-year Project Grant (CFDA 93.855 - Allergy and Infectious Diseases Research) worth $162,000 to The Johns Hopkins University to study how atypical B cells can be used to enhance vaccine responses in immunosuppressed individuals. The research project aims to define populations of immunosuppressed individuals who utilize these atypical CD11c+ B cells, assess their interaction with T cells, and target fatty acid oxidation...
This federal Project Grant award of $586,250 from the National Institute of Allergy and Infectious Diseases (NIAID) under CFDA 93.855 Allergy and Infectious Diseases Research program supports research to investigate how distinct age-associated B cell subsets can protect the aged from influenza. The project aims to determine the potential of different age-associated B cell subsets to respond to influenza infection and generate antibody-secreting cells, B cell memory, and long-lived...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $534,242 to the New York Blood Center, Inc. to study immune and behavioral responses to seasonal COVID-19 vaccines in transgender women. The goal is to understand the impact of gender-affirming hormone therapy on immune responses and facilitate evidence-based uptake of COVID-19 vaccines within the transgender...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $1,526,780 to Western Michigan University Homer Stryker M.D. School of Medicine to conduct research on the role of biological sex in the self-renewal of B1 cells into old age in mice and humans. The goal is to determine whether defects in natural immunity in the aged are due to changes in self-renewal of B1 cells, which produce natural antibodies. The research will utilize advanced genetic...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under CFDA 93.855 Allergy and Infectious Diseases Research, provides $3,056,673 to The Johns Hopkins University to conduct research on the immunologic mechanisms associated with hepatitis B (HBV) vaccine responses in people living with HIV (PLWH). The key objectives are to: 1) Define the innate immune signatures of the HBV vaccine adjuvants CpG 1018 and alum, 2) Compare HBV-specific B and T cell...
This $1,542,980 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), will fund research to explore the impact of gender-affirming hormone therapy on HIV viral dynamics and immune responses in transgender women. The award supports two key research cohorts: 1) a cross-sectional cohort of 120 transgender women, evenly divided by HIV serostatus and hormone exposure, and 2) a cohort of...
This five-year, $813,838 project grant from the National Institute of Allergy and Infectious Diseases will fund research into the genetic and hormonal mechanisms underlying sex differences in tuberculosis (TB) and TB-HIV coinfection. The Johns Hopkins University will investigate how X chromosome complement and sex steroid hormones impact TB pathogenesis using cellular models, animal studies, and human samples. Researchers will utilize a novel four core genotype mouse model to differentiate the...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) provides $837,497 to Yale University to conduct research focused on understanding the role of PI3K-gamma in regulating antibody responses. The 5-year project aims to elucidate the molecular mechanisms by which PI3K-gamma signaling in B cells supports the differentiation of antibody-secreting cells. The research has important implications for enhancing...