Project Grant HT94252510067

This Project Grant award of $906,019 from the National Institute on Aging (NIA) under CFDA 93.866 Aging Research aims to develop an engineered probiotic Akkermansia muciniphila strain for the treatment of Alzheimer's disease (AD). The project will involve screening A. muciniphila isolates to identify the top candidates, then engineering the strain to produce anti-inflammatory compounds such as butyrate, beta-hydroxybutyrate, and tauroursodeoxycholic acid (TUDCA) to reduce neuroinflammation and...

This federal Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), provides $548,949 to the University of California, San Diego (UCSD) to develop a novel diagnostic technique that can record and measure gut microbiota composition and spatial structure without invasive procedures. The awarded research aims to create living biosensors...

Biomesense Inc. received a $883,212 Project Grant award from the National Institutes of Health's National Center for Advancing Translational Sciences to develop a novel biosensor to accelerate investigations of the gut microbiome. The grant will support validating the microbial lysis and DNA isolation functions of a prototype biosensor over a 6-month period ending December 31, 2021. The biosensor is intended to enable dense, time-longitudinal sampling of participants' gut microbiomes in their...

This federal Project Grant award from the National Center for Complementary and Integrative Health (NCCIH), under the Research and Training in Complementary and Integrative Health Program (CFDA 93.213), provides $295,780 to Nemalife Inc. to develop a high-throughput in vivo screening platform for identifying novel probiotic and postbiotic bacterial strains. The objective is to create a cost-effective and scalable screening system using the nematode Caenorhabditis elegans as a model organism to...

This Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), is for a $683,916 project to develop a novel probiotic delivery system to prevent and treat neurodevelopmental impairment (NI) in premature infants. The central focus is on using a protective biofilm-encapsulated probiotic, Limosilactobacillus reuteri (LR), to mitigate the effects of necrotizing enterocolitis...

This Project Grant awarded by the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), will support research to investigate how the gut microbiome composition impacts gastrointestinal (GI) and central nervous system (CNS) function in a mouse model of autism spectrum disorder (ASD). The $430,375 award to the partnership between Henry Ford Health and Michigan State University Health Sciences will...

This $650,000 Project Grant awarded by the National Center for Advancing Translational Sciences (NCATS), under CFDA Program 93.350, supports research and development for a next generation probiotics-based platform technology to enable oral delivery of peptide and protein therapeutics. Specifically, the project aims to (1) develop an antibiotic-resistance-free expression system for stable, high-level production of therapeutic peptides in Lactobacillus probiotic strains, (2) create inducible...

This Cooperative Agreement award from the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310) provides $470,309 in funding to Chromologic LLC, a minority-owned small business in Monrovia, CA, to develop an orally administered probiotic-based treatment for mitigating radiation-induced gastrointestinal and hematopoietic injuries. The project aims to engineer a genetically modified Limosilactobacillus reuteri probiotic strain that...

This Project Grant award from the National Center for Complementary and Integrative Health (NCCIH), under the Research and Training in Complementary and Integrative Health program (CFDA 93.213), will support research to investigate the effects of gut microbiome dysbiosis on the transport of short-chain fatty acids (SCFAs) and its relevance to autoimmune disorders, such as multiple sclerosis (MS). The $863,500 award, with a period of performance from September 2024 to August 2026, will fund...

This federal Project Grant award, valued at $1,391,376.00 and provided by the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310), aims to identify and characterize the interactions between the gut microbiota, psychostimulant exposure, and the development of substance use disorders (SUDs). The principal investigators at Rutgers, The State University will apply a multidisciplinary approach combining metagenomics, metabolomics,...