Project Grant HT94252410161

This Project Grant from the National Institute on Aging, part of the Department of Health and Human Services, will fund research into the molecular interplay of sleep and neurodegeneration using the Drosophila model system. With $2.14 million provided over 11 months, the Trustees of the University of Pennsylvania will investigate how expression of the TDP-43 protein linked to neurodegenerative diseases disrupts sleep in fruit flies. Researchers will aim to define the specific glial subtypes...

This National Science Foundation (NSF) Social, Behavioral, and Economic Sciences (CFDA 47.075) Project Grant award provides $160,000 in funding to support a postdoctoral fellowship investigation into how sleep facilitates the integration of new and existing memories. The goal is to understand the brain mechanisms that enable this integration process, which is critical for building knowledge from new information encountered in daily life. The study will use electroencephalography (EEG),...

This federal Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), aims to study the relationship between mitochondrial dysfunction and the impact of non-syndromic autism spectrum disorder (ASD)-related risk genes on neuronal structure and function. The $253,500 award, provided from April 2025 to March 2027, will support the development of...

This $3.21 million cooperative agreement from the National Institutes of Health's National Institute of Neurological Disorders and Stroke will fund research at the California Institute of Technology to develop whole-brain functional imaging and analysis tools to study sleep regulation in zebrafish. Over a three-year period from May 2022 to April 2025, the awardee will use two-photon selective plane illumination microscopy to record neuronal activity with single-cell resolution during natural and...

This National Science Foundation Project Grant of $255,851 awarded on September 15, 2022 will support the development of a neuromodulation device to promote healthy sleep cycles through the completion of prototype engineering. The awardee, Neurolight Inc. of Suffern, New York, will utilize controlled light and sound stimuli delivered via an externally worn system to transpose normal brain wave patterns associated with desired sleep states into recipients suffering from sleep disorders. This aims...

Federal Grant Award Summary The Eunice Kennedy Shriver National Institute of Child Health and Human Development awarded a $165,000 Project Grant to Massachusetts General Hospital (The General Hospital Corporation) under the Child Health and Human Development Extramural Research program (CFDA 93.865) for the period August 1, 2025 through July 31, 2027. The research project investigates the cerebrospinal fluid (CSF) system in children with autism spectrum disorder (ASD), with particular focus on...

This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program provides $440,640.00 to the University of Arizona to investigate the use of oscillating electromagnetic fields to modulate glymphatic system activity and brain waste clearance. The research aims to measure the global and regional impacts of slow-wave brain activity entrainment on glymphatic...

This $408,541 Project Grant was awarded by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) to Drexel University in Pennsylvania. The grant supports research to investigate the role of a subpopulation of neurons in the retrosplenial cortex in initiating sleep patterns that facilitate memory consolidation. The key objectives are to study the neural dynamics of these "Down-State Assembly" neurons and their involvement in...

The National Science Foundation awarded a $256,000 Small Business Innovation Research Phase I Project Grant to Lumostech, Inc. under the Technology, Innovation, and Partnerships program (CFDA 47.084) to develop a smart sleep mask and mobile application to improve sleep for adolescents. The one-year project will apply light flash technology delivered through a sleep mask to advance teenagers' circadian phases without disrupting daytime activities. Cognitive behavioral therapy delivered via mobile...

Summary: Neurophysiological Correlates of Cognition Over Multi-Day Timescales in Epilepsy The National Institute of Neurological Disorders and Stroke (NINDS) awarded Massachusetts General Hospital $234,630 on August 1, 2025, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to conduct a five-year prospective research study examining the neurophysiological basis of cognitive impairment in temporal lobe epilepsy (TLE). The research...