Project Grant HT94252310881

This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) is funding research to develop a new type of bioprosthetic aortic valve made from pulmonary visceral pleura (PVP) tissue. The $742,323 award to Vanderbilt University aims to evaluate the mechanical and hemodynamic performance of the PVP aortic valve compared to existing bioprosthetic valves through in vitro experiments, computational modeling, and...

This Project Grant award of $786,188.00 from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) supports research to develop a targeted gene therapy platform to prevent prosthetic bypass graft failure. The proposed approach involves using a novel biodegradable gelatin hydrogel to deliver small interfering RNA (siRNA) targeting specific genes, such as TSP-2 and MARCKS, that drive the development of intimal hyperplasia and graft...

The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a $300,000 Project Grant (CFDA 93.846) to Collamedix Inc., a for-profit medical biotechnology company, to develop and evaluate the feasibility of ALLOBRACE, a pure collagen sheath designed to enhance soft tissue allograft healing and integration for anterior cruciate ligament (ACL) reconstruction. The funding supports preclinical studies using a porcine model to refine the ALLOBRACE design and evaluate...

The National Heart, Lung, and Blood Institute (NHLBI) awarded a 1-year, $834,249 Project Grant (CFDA 93.837 - Cardiovascular Diseases Research) to Cedars-Sinai Medical Center to conduct a comparative study of clinical outcomes, patient experiences, and mechanistic insights between transcatheter and surgical treatment of degenerative mitral regurgitation. The study aims to: Leverage Cedars-Sinai's institutional infrastructure to follow approximately 1,800 patients (900 transcatheter and 900...

This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $385,381 to the Trustees of Tufts College (Tufts University) to develop and evaluate injectable, highly elastic silk-extracellular matrix (ECM) composite hydrogels for cardiac tissue repair following myocardial infarction. The central hypothesis is that these dynamic biomaterials, including fetal heart-derived ECM components, will provide...

The National Science Foundation (NSF) has awarded a $455,718 Faculty Early Career Development (CAREER) Project Grant to Marquette University to develop a living, tissue-engineered heart valve substitute capable of growing with child recipients of congenital heart valve defects. The 5-year project, funded under the NSF Engineering program (CFDA 47.041), aims to create a durable, hydrodynamically functional heart valve using an origami-inspired design and patient-derived cells that can self-repair...

The National Institutes of Health's National Heart, Lung and Blood Institute awarded Fluidform Inc. a $766,107 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) from April 1, 2021 to March 31, 2022. The grant funds the development of an advanced bioprosthetic collagen heart valve using 3D printing techniques to recreate the collagen fiber architecture and mechanical properties of native heart valve leaflets. Fluidform will collaborate with Carnegie Mellon...

The National Heart, Lung, and Blood Institute (NHLBI) awarded a $676,970 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to the Geisinger Clinic in Danville, Pennsylvania. The 5-year grant, which runs from August 2024 to May 2029, will fund research to investigate the physiological effects of pulsatile versus non-pulsatile blood flow using an impeller-based total artificial heart device. The research aims to characterize the impact of different flow patterns on...

This three-year, $873,284 National Institutes of Health National Institute of Allergy and Infectious Diseases project grant to the University of Arkansas supports research into the effects of SARS-CoV-2 infection on calcific aortic valve disease. Specifically, the university researchers will examine angiotensin-converting enzyme 2 (ACE2) expression and renin-angiotensin system signaling at various stages of valve disease using human tissue samples. They will also develop a three-dimensional...

This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research federal grant program (CFDA 93.837) provides $738,356 to the University of Pittsburgh to develop and validate a tissue-engineered vascular graft (TEVG) device for potential clinical translation. The primary objectives are to: 1) Evaluate the TEVG constructs in vitro using industry-standard quality assessments; 2) Conduct in vivo evaluation of human-sized TEVG grafts in a...