Project Grant FA95502410186

This federal Project Grant award, with ID R21AG086520, was provided by the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866). The $654,500 grant will fund a study to evaluate the impact of chronic hypoxia exposure, as experienced at high altitudes, on the risk and symptoms of major depressive disorder in aging, with a focus on sex differences. The study will utilize a translational animal model to assess the effects of chronic hypoxia exposure on depression-like...

This $472,500 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will support research to investigate the ability of low oxygen (hypoxia) therapy to rescue mitochondrial diseases caused by mutations in the mitochondrial proteostasis system. The research aims to elucidate two potential mechanisms of hypoxia-mediated rescue: (1) activation of the hypoxia-inducible factor (HIF) transcriptional response to promote metabolic adaptations, and (2) stabilization of...

This $633,045 federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) aims to investigate the pathogenic mechanisms and potential therapeutic approaches for exercise intolerance in patients with post-acute sequelae of COVID-19 (PASC). The key objectives are to: 1) Investigate the predictive value of angiotensin-converting enzyme 2 (ACE2) activity as a clinical biomarker and its association with...

This $467,473 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) will fund research by Virginia Commonwealth University to investigate the role of the acid ceramidase-sphingosine-1-phosphate (AC-S1P) pathway in the kidneys and its impact on salt-sensitive hypertension. The key objectives are to: 1) Determine if activation of the AC-S1P pathway in the...

This federal Project Grant award for $605,678 from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) supports research into a novel mechanism regulating genome-wide mRNA expression in hypoxic lung disease. The research aims to explore the prospect that hypoxia activates a pathway operating in concert with hypoxia-inducible transcription factors (HIFs) to govern the hypoxic transcriptome. Specifically, the project will...

This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $480,990 to the University of Illinois to investigate the role of aerocytes, a recently identified capillary endothelial cell population, in regulating alveolar epithelial regeneration following lung injury. The research aims to establish the central role of aerocytes and the signaling molecule R-spondin3 in guiding the...

This Project Grant award from the National Institutes of Health's (NIH) Child Health and Human Development Extramural Research program (CFDA 93.865) provides $234,000.00 to the University of Colorado-Denver to investigate the role of a novel NF-kB genetic variant in the development of preeclampsia, a serious vascular disorder during pregnancy. The research aims to establish whether this genetic variant is associated with impaired placental development, elevated inflammatory cytokines, reduced...

This $190,491 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) supports research to characterize circulating plasma protein markers associated with the blood pressure response during exercise and their relationship to future hypertension and cardiovascular disease risk. The research will be conducted by the Beth Israel Deaconess Medical Center, Inc. (Bidmc) in Boston, MA. Key objectives include: 1)...

This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research federal grant program (CFDA 93.837), provides $131,273 to The Trustees of Columbia University in the City of New York to investigate the epigenetic basis of socioeconomic determinants of cardiometabolic health in American Indian populations. The key objectives of this research project are to: 1) Examine socioeconomic determinants of cardiometabolic health; 2)...

This Project Grant award of $305,447, issued on September 2, 2024 by the National Institute of Child Health and Human Development (CFDA 93.865 - Child Health and Human Development Extramural Research), aims to identify predictive biomarkers for acute intermittent hypoxia-induced motor recovery in individuals with incomplete spinal cord injury. The research team from the University of Colorado will: 1) Validate the cellular mechanisms underlying hypoxia-induced plasticity in humans, using...