This $378,250 Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) will support research into the regulation of skeletal growth and regeneration. The project, led by The Children's Hospital of Philadelphia Research Institute, aims to assess growth plate dysfunction, delineate the underlying cellular mechanisms, and test the effectiveness and safety of...
The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a $144,362 Project Grant (CFDA 93.846) to The Johns Hopkins University to investigate the critical biological decision-making processes that guide the differentiation of chondrocyte progenitor cells during synovial joint and bone development. The primary objectives are to: 1) determine the antagonistic effects of transcription factors like PITX1 and ATF4 in promoting the expression of articular cartilage...
This $626,879 federal project grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) supports research dedicated to exploring a novel mouse model of large-scale bone regeneration. The primary objectives are to investigate the mechanisms that trigger activation of sentinel-type Sox9-lineage cells in response to injury, determine if these cells recruit bone marrow...
This $522,334 federal Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), will fund the development of a computational infrastructure and data repository called "BoneBase" to collect and share bone phenotyping data generated by researchers studying rodent animal models. The project aims to build a sustainable, globally-accessible platform for...
This Project Grant award for $375,100.00, granted by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), will fund research to identify myeloid progenitors that aid in maintenance of cortical bone with age and characterize cells/molecules that promote coupling within cortical bone. The two-year project, awarded on September 20, 2024 with an ultimate completion date of August 31,...
This federal Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), provides $526,174 to Duke University to engineer heterocellular human skeletal muscle tissues. The goal is to recreate and study the native stem cell niche function in healthy skeletal muscle, which is critical for regeneration. The research will increase the cellular complexity of the...
This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), provides $599,693 to The Hospital For Special Surgery Fund, Inc. for a 5-year period from August 1, 2024 to July 31, 2029. The research aims to elucidate molecular pathways and mechanisms that regulate myeloid cell function and osteoclastogenesis (bone-resorbing cell formation) under pathological...
This $426,889 Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) supports research into the molecular regulatory mechanisms of a cartilage-enriched G protein-coupled receptor (GPCR) called ADGRG6 in maintaining joint and cartilage homeostasis. The key objectives are to: 1) investigate the chondrocyte-specific role of ADGRG6 using genetic deletion, 2)...
This federal Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), provides $1,034,838 to support research into the regulation of stem cell niches in skeletal muscle. The primary aim is to investigate how neutrophil serine proteases, specifically neutrophil elastase, influence muscle stem cell activation and the overall muscle stem cell niche. The...
This $439,791 federal Project Grant award was provided by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The grant supports a research project at the University of Texas Southwestern Medical Center that aims to investigate the molecular mechanisms underlying myoblast fusion, which is essential for skeletal muscle development and regeneration. The key products and services...