Project Grant R01AI190033
- The National Institute of Allergy and Infectious Diseases awarded the Trustees of Indiana University $658,213 on July 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate how chronic viral infections suppress dendritic cell function and impair secondary immune responses. The research examines mechanisms by which persistent viral infections such as HIV and hepatitis B and C alter CD8 T cell priming through decreased dendritic cell activation. The...
- The National Institute of Allergy and Infectious Diseases, part of the Department of Health and Human Services, awarded $158,500 to Trustees of Indiana University (doing business as Indiana University Indianapolis) on April 10, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855). The award funds development of a novel mouse model to analyze FOXP3+ T follicular helper (TFH) cells and their role in immune responses. The research addresses how follicular T regulatory...
- The National Institute of Allergy and Infectious Diseases awarded the Trustees of Indiana University $370,835 on August 18, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to develop a computational framework for analyzing HIV immune escape across viral diversity. The funded research addresses a critical gap in HIV immunology: the lack of a rigorous computational approach capable of distinguishing universal, robust escape mechanisms from noise caused by...
- The National Institute of Allergy and Infectious Diseases awarded the Trustees of Indiana University $700,209 on May 12, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate the impact of high-salt diets on CD8 T cell responses to acute viral infection. The research will test the hypothesis that excessive salt consumption rapidly impairs CD8 T cell capacity to respond to viral infections through both extrinsic and intrinsic mechanisms. Preliminary data...
- The National Institute of Allergy and Infectious Diseases awarded Trustees of Indiana University (doing business as Indiana University) $617,374 on August 7, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to define nuclear pore complex subsets and import pathways that regulate HIV-1 integration and gene expression. The research will characterize how HIV-1 exploits nuclear pore complex remodeling and host factors to gain access to the nucleus in non-dividing cells,...
- The National Institute of Allergy and Infectious Diseases awarded The University of Iowa $427,625 on February 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to support research on how TRAF3 regulates CD4 T cell differentiation and function during chronic infections. The research employs single-cell technologies and cutting-edge genomic and epigenetic approaches—including single-cell RNA sequencing—to dissect how TRAF3 integrates T cell receptor, cytokine, and...
- The National Institute of Allergy and Infectious Diseases awarded The Trustees of Columbia University in the City of New York $622,850 on September 2, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate the heterogeneous functions, antigen specificities, and lipid antigen restrictions of human CD4-/CD8- double-negative T cells (DN T cells). The research examines how CD1-restricted DN T cell populations respond to CD1-presented self-lipid antigens and...
- The National Institute of Allergy and Infectious Diseases (NIAID) has awarded a $781,367 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to Weill Medical College of Cornell University. The grant, awarded on January 25, 2024, will support research to define and maximize the impact of CD8+ T-cell selection on the landscape of HIV integration sites. The goal is to optimize strategies for eradicating the persistent reservoir of HIV-infected cells and achieve...
- The National Institute of Allergy and Infectious Diseases awarded Scripps Research Institute $552,000 on August 3, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to conduct functional characterization of dendritic cell heterogeneity for T cell-inducing immunotherapies. The research addresses vaccine development for intracellular pathogens including HIV/AIDS and malaria by investigating the distinct roles of type 1 and type 2 conventional dendritic cells in...
- The National Institute of Allergy and Infectious Diseases, part of the Department of Health and Human Services, awarded $790,946 to Indiana University Indianapolis on February 10, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate dysregulation of humoral immunity following Plasmodium infection. The research examines why Plasmodium infections fail to induce long-lasting antibody protection, unlike most other infections and vaccines. The project...
The National Institute of Allergy and Infectious Diseases awarded the Trustees of Indiana University $710,142 on September 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to conduct research on CD4 TH1 cell restoration for control of chronic viral infections. The project, awarded as a Project Grant (R01AI190033), runs through August 31, 2031, with place of performance in Indianapolis, Indiana. The research addresses T cell exhaustion driven by prolonged antigen stimulation in chronic viral infections such as HIV and hepatitis B and C. The funded work investigates how reconstitution of CD4 TH1 cells enhances CD8 T cell numbers and function and accelerates viral clearance. The research examines anti-PDL1 treatment as a mechanism to target and enhance virus-specific CD4 TH1 cells, and explores the cytotoxic capacity of CD4 TH1 cells to kill MHC II–positive target cells in vivo—a function lost during chronic infection. A specific focus includes the role of cytotoxic TH1 cells in lysing virally infected dendritic cells and supporting antiviral CD8 T cell responses. The Allergy and Infectious Diseases Research program supports biomedical research and training in infectious diseases and related areas at public and private nonprofit institutions, universities, and research organizations, with competitive applications reviewed for scientific merit and national advisory council evaluation.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $710.1k | 8/25/26 |