Project Grant F31HD120032
- The National Institute of Child Health and Human Development awarded The Trustees of The University of Pennsylvania $149,190 on January 1, 2026, under the Child Health and Human Development Extramural Research Projects program (CFDA 93.HDR) to elucidate the biochemical mechanisms of SCMH1, an accessory subunit of polycomb repressive complex 1, during cellular differentiation. The research investigates SCMH1's role in polycomb-mediated gene repression through RNA-binding and nuclear condensation....
- The National Institute of Child Health and Human Development awarded the University of Pennsylvania $100,228 on January 1, 2027, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to investigate long-lived cardiac myosins as regulators of oocyte cytoskeletal integrity and reproductive lifespan. The research examines how exceptionally long-lived proteins—specifically A- and B-cardiac myosin heavy chain proteins (MHC-A/-B)—maintain oocyte cytoskeletal...
- The National Institute of Child Health and Human Development awarded The Trustees of the University of Pennsylvania $704,336 on August 17, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to investigate the role of T cells in transgenerational epigenetic inheritance. The funded research examines how the immune system, specifically T cells, can epigenetically alter phenotypes across multiple generations of progeny. Preliminary data demonstrates that T...
- The National Institute of Child Health and Human Development awarded Duke University $686,184 on July 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to conduct research on the transcriptional and environmental regulation of lysosome-rich enterocytes. The research characterizes the mechanisms governing formation and function of lysosome-rich enterocytes (LREs) in the neonatal ileum, specialized absorptive cells that uptake and digest dietary...
- The National Institute of Child Health and Human Development awarded Pennsylvania State University operating as Penn State Milton S. Hershey Medical Center $679,059 on September 3, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to conduct research on thiamine supplementation as an intervention to prevent neurologic sequelae in infants with invasive bacterial infections. The research, titled "Thiamine for Recovery in Vulnerable Early-Life...
- The National Institute of Child Health and Human Development awarded The Trustees Of The University Of Pennsylvania $134,325 on September 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to support a K99 Transition to Independence Award (K99HD122914) investigating mechanisms of bone morphogenetic protein (BMP) signaling through receptor sub-functionalization. The research examines how type I receptor sub-functions regulate BMP signaling by...
- The National Institute of Child Health and Human Development awarded the University of Maryland, College Park $156,000 under the Child Health and Human Development Extramural Research program (CFDA 93.865) on June 17, 2026. The award funds research into intrinsic and extrinsic mechanisms underlying trigeminal nerve deficits in familial dysautonomia (FD), a rare hereditary neuropathy caused by a splice site mutation in the elongator acetyltransferase complex subunit 1 (ELP1) gene. FD patients...
- The National Institute of General Medical Sciences awarded Pennsylvania State University operating as Penn State Milton S. Hershey Medical Center $410,773 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate mitochondria-lysosome crosstalk in health and disease. The research addresses how direct inter-communication between mitochondria and lysosomes affects cellular function and disease. The project examines how membrane contact sites...
- The National Institute of Child Health and Human Development awarded The Pennsylvania State University $470,816 on June 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to investigate molecular and metabolic mechanisms governing secretory activation and milk volume in mothers with infants in the neonatal intensive care unit. The research uses transcriptomic and biochemical analysis of inflammatory and lipid metabolism pathways to identify biological...
- The National Institute of Child Health and Human Development awarded the University of Maryland, College Park $424,743 on June 25, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to investigate the molecular basis of R249W LMNA-related congenital muscular dystrophy and explore therapeutic strategies. The research examines three specific aims: characterizing how the R249W mutation affects skeletal muscle development; studying lamina organization and...
The National Institute of Child Health and Human Development awarded the University of Pennsylvania $100,228 on November 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to support research into TRPML1 regulation and its role in lysosomal morphology and function. The research addresses knowledge gaps in lysosomal biology, focusing on how the transient receptor potential mucolipin 1 (TRPML1) ion channel regulates lysosomal function and morphology. TRPML1 mediates calcium and cation flux from the lysosomal lumen to the cytosol and plays roles in diseases including Alzheimer's disease, Parkinson's disease, Duchenne muscular dystrophy, and mucolipidosis type IV. The project examines TRPML1 modulation through small molecule modulators PRU-12 and MK6-83, with prior evidence linking PRU-12 to reduced migration and invasion in triple-negative breast cancer cells and MK6-83 to restoration of activity in TRPML1 mutants associated with mucolipidosis type IV. The award period runs through June 30, 2028. Work is performed in Philadelphia, Pennsylvania.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $0 | 5/29/26 | ||
| Not listed | $50.1k | 5/29/26 | ||
| Not listed | $50.1k | 5/29/26 |