Project Grant F31ES027317

This Project Grant award from the National Center for Advancing Translational Sciences (NCATS), under the CFDA Program 93.350 - National Center for Advancing Translational Sciences, will provide $148,248 to Michigan State University to conduct research aimed at screening variants of the manganese transporter SLC39A8 to identify pathogenic variants. The primary objectives are to: 1) Develop and apply a high-throughput cell-based transport assay to screen nearly 300 SLC39A8 variants for impaired...

This Project Grant award from the National Institute of Environmental Health Sciences (NIEHS), under the Environmental Health (CFDA 93.113) federal grant program, provides $682,698 to Florida A&M University (FAMU) to investigate the mechanisms of manganese-induced neurotoxicity mediated through the protein Leucine Rich Repeat Kinase 2 (LRRK2) in microglia. The 5-year project aims to elucidate how manganese exposure increases LRRK2 expression and kinase activity in microglia, leading to...

This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) provides $671,775 to the Icahn School of Medicine at Mount Sinai to conduct structural and drug discovery research on neuronal SLC4 transporters. The key objectives are to: (1) elucidate the substrate stoichiometries of the SLC4A7, SLC4A8, and SLC4A10 transporters; (2) develop subtype-selective and...

This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, will support research to determine the role of the CNNM2 protein in regulating magnesium homeostasis in neurons, and how disruptions in this process contribute to neurological disorders. The $274,750 award to Rutgers, The State University of New Jersey will fund a 2-year research project to...

This Project Grant award of $534,160 from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) supports advanced research on the molecular mechanisms underlying intracellular ion transport and genome maintenance. The award to the Sloan-Kettering Institute for Cancer Research in New York will fund a 5-year research program focused on four key areas: Elucidating the mechanisms by which ion transport proteins, such as TMEM175,...

This federal Project Grant award of $107,948 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) supports research to investigate the relationship between extracellular citrate levels and neuronal excitability in a genetic form of epilepsy known as SLC13A5 epilepsy. The principal investigator will use advanced imaging, electrophysiology, and mass spectrometry techniques in...

This federal Project Grant award, funded by the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health (CFDA 93.113) program, supports the South African Manganese Environmental Neurotoxic Effects Research (SMELTER) study. The $585,531 award, with a performance period from September 1, 2024 to June 30, 2029, aims to examine the neurological health effects associated with manganese exposure in a cohort of over 800 South African residents. The study involves...

The National Institute of Environmental Health Sciences (NIEHS) awarded a $441,529 Project Grant under the Environmental Health (CFDA 93.113) federal grant program to the University of Georgia Research Foundation, Inc. (UGA Research Foundation) on November 15, 2024. The grant supports research to elucidate the role of epitranscriptomic mechanisms, specifically N6-methyladenosine (m6A) RNA modification, in regulating astrocyte activation and neuroimmune dysfunction induced by chronic exposure...

This $688,904 Project Grant award from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health (CFDA 93.113) program supports research to investigate the mechanisms linking developmental manganese (Mn) exposure, dopamine dysregulation, and the increased frequency of ADHD diagnoses. The research, conducted by Vanderbilt University Medical Center (VUMC) and sub-awardees Purdue University and Vanderbilt University, aims to deepen the understanding of...

This Project Grant award of $769,644 from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) supports research to functionally characterize the lysosome membrane and its protein quality control system. The primary objectives are to: 1) identify substrates of lysosomal E3 ligases in humans, 2) investigate the assembly of the ESCRT machinery to the lysosome membrane for internalizing ubiquitinated cargoes, and 3) determine the...