This Project Grant award of $502,742 from the National Institute on Deafness and Other Communication Disorders (NIDCD), under the Research Related to Deafness and Communication Disorders program (CFDA 93.173), will support research at Duke University to investigate the fundamental principles of olfactory processing in the mammalian brain. The research aims to uncover how the piriform cortex in the brain encodes and represents olfactory information, leveraging innovative techniques to record from...
This $380,376 federal Project Grant award from the National Institute on Deafness and Other Communication Disorders (NIDCD) under CFDA program 93.173 "Research Related to Deafness and Communication Disorders" will support research at Brown University on the convergence of behavioral and sensory information in the olfactory cortex of mice. The key objectives are to: 1) Determine whether behavioral signals in the piriform cortex support predictive processing of odor information, and 2)...
This federal Project Grant award from the National Institute on Deafness and Other Communication Disorders (NIDCD), under the Research Related to Deafness and Communication Disorders program (CFDA 93.173), is funding research into the mechanisms of odor detection and discrimination in the mammalian olfactory system. The $650,049 award to Duke University will investigate the structural determinants of odorant receptor (OR) activation and the corresponding neural signaling in awake, freely...
This federal Project Grant award for $423,500 from the National Institute on Deafness and Other Communication Disorders (NIDCD) under CFDA 93.173 - Research Related to Deafness and Communication Disorders will fund research at Florida State University to investigate how the piriform cortex (PCX) region of the brain encodes olfactory information. The research project aims to examine how individual and ensemble PCX neurons encode odor identity across different concentration regimes, and how...
This federal Project Grant award for $665,886.00 from the National Institute on Deafness and Other Communication Disorders (NIDCD) under the Research Related to Deafness and Communication Disorders program (CFDA 93.173) will support research to characterize the transformation of odor responses from the olfactory bulb to higher brain areas and reveal its significance for information processing. The project aims to leverage recent technological advances in 2-photon calcium imaging and...
This federal Project Grant award from the National Institute on Deafness and Other Communication Disorders (NIDCD), under the Research Related to Deafness and Communication Disorders program (CFDA 93.173), provides $682,219 to Duke University to conduct research aimed at defining the mechanisms driving olfactory neuronal homeostasis and dysfunction in humans. The key products or services to be delivered under this award include: 1) Establishing the axes of transcriptional variation in human...
This Project Grant award from the National Institute on Deafness and Other Communication Disorders (NIDCD), under the Research Related to Deafness and Communication Disorders program (CFDA 93.173), provides $1,658,036 to the University of Rochester to investigate the role of hippocampal feedback projections on the function of the early olfactory system. The project aims to study the circuit between the ventral CA1 region of the hippocampus and the main olfactory bulb to understand how...
This Project Grant award from the National Institute on Deafness and Other Communication Disorders (NIDCD), under the Research Related to Deafness and Communication Disorders program (CFDA 93.173), will provide $558,930.00 to the University of Virginia to conduct an intensive longitudinal assessment of human olfaction (i.e., smell). The study aims to document typical olfactory fluctuations in healthy adults, changes in olfactory function associated with the menstrual cycle or pregnancy, and...
This $1,836,842 Project Grant from the National Institute of Neurological Disorders and Stroke will support research into sensory-motor strategies for odor-guided navigation. Funded under the Extramural Research Programs in the Neurosciences and Neurological Disorders program, the Trustees of Boston University will conduct research to better understand how spatial information is encoded in the olfactory bulb during odor-guided search behaviors in mice. Researchers will use new imaging tools to...
This $1,400,787 project grant from the National Institutes of Health's National Institute on Deafness and Other Communication Disorders will fund research into the behavioral and neural substrates of odor-guided navigation in the human brain from January 2022 through December 2026. The grant supports research aligned with the Research Related to Deafness and Communication Disorders program to investigate solutions to problems directly relevant to individuals with disorders of human communication...
This Project Grant award of $216,714 from the National Institute on Deafness and Other Communication Disorders (NIDCD), under the Research Related to Deafness and Communication Disorders program (CFDA 93.173), supports research to investigate the neural circuitry underlying how the brain processes and assigns emotional significance to odors.
The key objectives are to test the hypothesis that neurons in the basolateral amygdala (BLA) represent the full spectrum of learned odor valence, both positive and negative, and that dopamine regulates the display of learned odor valence behaviors. The research will use a combination of electrophysiological and computational methods, optogenetic stimulation, and site-specific pharmacology as mice engage in a behavioral task where odors are either rewarded or punished. This research aims to enhance understanding of how the brain processes emotional responses to odors and the role of dopamine in olfactory processing, with implications for disorders characterized by disturbed affective regulation.