This $650,049 federal Project Grant award from the National Institute on Deafness and Other Communication Disorders (NIDCD) under CFDA Program 93.173 "Research Related to Deafness and Communication Disorders" supports research to investigate the structural determinants of odorant receptor (OR) activation and corresponding neural signaling in the mouse olfactory system. The project aims to 1) characterize the in vitro activation profiles and in vivo response features of three odorant receptors (one Class I and two Class II) and test hypotheses on how OR activation translates to neural activity patterns, and 2) investigate the structural basis and in vivo efficacy of OR antagonism in shaping odorant-evoked neural activity. This research, conducted by Duke University, is expected to provide new insights linking olfactory sensing mechanisms from the receptor level to neural activity in the brain, enable rational design of OR antagonists, and achieve a generalizable understanding of the relationship between OR structure, ligand selectivity, and OR-driven neural activity.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $650.0k | 4/29/25 |