This Project Grant award from the National Institute on Deafness and Other Communication Disorders (NIDCD), under the Research Related to Deafness and Communication Disorders program (CFDA 93.173), provides $502,742 to Duke University to conduct research focused on uncovering fundamental principles of sensory processing in the mammalian brain. Specifically, the research aims to examine how the piriform cortex encodes and represents olfactory information, with the goal of advancing the understanding of neural coding and its implications for sensory neuroscience. The 5-year project will leverage innovative techniques to record from hundreds of neurons in the piriform cortex of awake, head-fixed mice, while using optogenetics to precisely stimulate the olfactory bulb and manipulate neural circuits. This work is expected to reveal a novel framework for understanding how odor information is encoded in the piriform cortex, which could eventually lead to new strategies for diagnosing and treating sensory processing disorders.
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