This federal Project Grant award of $673,048 was provided by the National Institute on Deafness and Other Communication Disorders (NIDCD) under the Research Related to Deafness and Communication Disorders program (CFDA 93.173). The objective is to investigate the role of mitochondrial calcium regulation in cochlear hair cells and its contribution to acquired hearing loss, with a focus on assessing the impact of acoustic overstimulation and developing strategies to mitigate noise-induced...
This Project Grant award from the National Institute on Deafness and Other Communication Disorders (NIDCD), under the CFDA 93.173 Research Related to Deafness and Communication Disorders program, will support research on age-related auditory nerve degeneration and potential treatments. The $102,324 award, effective September 1, 2025 through August 31, 2027, will be administered by the Medical University of South Carolina. The key objectives are to: 1) Define age-dependent changes in Dectin-1...
The National Institute on Deafness and Other Communication Disorders (NIDCD) awarded a $1,277,317 Project Grant under the Research Related to Deafness and Communication Disorders program (CFDA 93.173) to the Medical University of South Carolina (MUSC). The award period runs from August 15, 2024 through May 31, 2029. The grant supports research to investigate the relationship between autism spectrum disorders (ASDs) and auditory system deficits, with a focus on the role of neuronal and immune...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) in the amount of $2,433,859 supports research at The Johns Hopkins University to investigate age-related hearing loss and cognitive decline. The key objectives are to study the molecular, cellular, and connectivity changes in the central auditory system during normal aging and Alzheimer's disease, with the goal of developing targeted therapeutic strategies. The research integrates single-cell sequencing,...
This Project Grant award from the National Institute on Deafness and Other Communication Disorders (NIDCD), under the Research Related to Deafness and Communication Disorders program (CFDA 93.173), provides $581,105 to Creighton University to develop natural-based therapies for treating hearing loss caused by aminoglycoside antibiotics. The key focus is on designing, synthesizing, and testing piperlongumine derivatives that can better target the TRPV1 channel to protect hair cells and synapses...
This federal Project Grant award of $477,660 from the National Institute on Deafness and Other Communication Disorders (CFDA 93.173 - Research Related to Deafness and Communication Disorders) supports research to investigate age-related brain differences that affect speech recognition in older adults. The primary objectives are to characterize how quickly older adults accumulate sensory evidence and how much evidence they require to make speech recognition decisions, and to link these perceptual...
The National Institute on Deafness and Other Communication Disorders (NIDCD) awarded a $115,707 Project Grant under the CFDA 93.173 Research Related to Deafness and Communication Disorders program to the Rector & Visitors of the University of Virginia (UVA). The grant supports research investigating how phospholipid homeostasis regulates hair cell function and health, using mouse models deficient in the phospholipid flippase ATP8B1 or its cofactor TMEM30B. The research aims to uncover the...
This federal Project Grant award of $610,725.00 was provided by the National Institute on Deafness and Other Communication Disorders (NIDCD) under the Research Related to Deafness and Communication Disorders program (CFDA 93.173). The grant will fund research at the University of Pittsburgh to investigate physiological mechanisms that contribute to suprathreshold deficits in speech understanding for individuals with sensorineural hearing loss. The key research activities include:...
This Project Grant award of $623,777 from the National Institute on Deafness and Other Communication Disorders (NIDCD), under the Research Related to Deafness and Communication Disorders program (CFDA 93.173), supports research on the role of the immune system and inflammation in hearing loss. The primary awardee, The Washington University, will conduct studies to examine how viral infections like cytomegalovirus (CMV) impact the development of the blood-labyrinth barrier in the inner ear and...
This Project Grant award from the National Institute on Deafness and Other Communication Disorders (NIDCD) under CFDA 93.173 "Research Related to Deafness and Communication Disorders" provides $637,500.00 to the Massachusetts Eye and Ear Infirmary to conduct research on understanding human cochlear micromechanics. The goal is to study the forward transduction that drives inner and outer hair cell stereocilia, as well as the reverse transduction that amplifies organ of Corti motion...
This Project Grant award was provided by the National Institute on Deafness and Other Communication Disorders (NIDCD) under the Research Related to Deafness and Communication Disorders program (CFDA 93.173) to The Medical University of South Carolina (MUSC). The $145,642 award, which began on September 1, 2024 and is scheduled to conclude on May 31, 2025, will support research investigating mitochondrial dysfunction as a driver of stria vascularis degeneration and inflammation in age-related hearing loss (presbyacusis). The project aims to evaluate the role of impaired mitochondrial quality control, including excessive mitochondrial fission and impaired mitophagy, in contributing to oxidative stress, macrophage activation, and inflammation within the stria vascularis of the aging cochlea. This research is expected to provide insights that may aid in the development of future therapeutic interventions to combat inflammation and preserve auditory function in the aging inner ear.