Project Grant F31CA314085
- The National Institutes of Health National Cancer Institute awarded Yale University $149,190 on December 27, 2025, under the Cancer Research Manpower program (CFDA 93.398) to support training and research in basic, clinical, and prevention research important to the National Cancer Program. The funded work investigates the anti-tumor roles of tumor-draining lymph nodes in renal cell carcinoma, examining how CD8+ T cells—critical mediators of anti-tumor immunity—differentiate and sustain immune...
- The National Cancer Institute awarded Yale University $100,228 on December 1, 2026, under the Cancer Research Manpower program (CFDA 93.398) to support research training and biomedical career development in cancer research. Yale will conduct basic research on the regulation of membrane-chromatin interactions during mitotic nuclear formation and their role in cancer cell survival. The project investigates how endoplasmic reticulum membranes and LEM-domain proteins, including LEMD2 and emerin,...
- The National Cancer Institute awarded Yale University $104,902 under the Cancer Research Manpower program (CFDA 93.398) on September 30, 2026, to support research investigating the immunobiology of tumor-specific T follicular helper CD4 T cells and their role in response to immune checkpoint blockade cancer therapies. The research employs spatiotemporal tracking, cyclic immunofluorescence, flow cytometry, and single-cell RNA sequencing to define factors that generate interleukin-21...
- Federal Grant Award Summary The National Cancer Institute awarded Yale University a $478,532 Project Grant under the Cancer Biology Research program (CFDA 93.396) effective September 1, 2025, through August 31, 2027. This research initiative will investigate the biological and clinical significance of spatial immune heterogeneity in non-small cell lung cancer (NSCLC), with particular focus on characterizing how the spatial distribution of tumor-infiltrating lymphocytes (TILs) and tertiary...
- The National Cancer Institute, part of the Department of Health and Human Services National Institutes of Health, awarded Yale University $696,189 on April 7, 2026, under the Cancer Biology Research program (CFDA 93.396) to investigate mechanisms of CD8 T cell differentiation in tumor-draining lymph nodes. The research examines how CD8 T cells—specifically progenitor-exhausted (TPEX) cells housed in tumor-draining lymph nodes associated with lung adenocarcinoma—maintain stemlike properties and...
- The National Cancer Institute, part of the Department of Health and Human Services, awarded the University of California Irvine $648,626 on April 2, 2026, under the Cancer Treatment Research program (CFDA 93.395) to investigate mechanisms of immunosuppression triggered by checkpoint blockade immunotherapy. The funded research examines why PD-1 checkpoint inhibitors fail in most cancer patients despite providing durable benefits in approximately 40 percent of patients with metastatic melanoma and...
- The National Cancer Institute awarded Yale University $577,750 on June 1, 2026, under the Cancer Cause and Prevention Research program (CFDA 93.393) to investigate the chromatin remodeling complex PBAF in small cell lung cancer. The research aims to elucidate the chromatin, epigenetic, and transcriptional mechanisms that promote small cell lung cancer development and to translate mechanistic findings toward clinical therapeutics. Yale's investigation focuses on recurrent inactivating mutations...
- The National Institutes of Health National Cancer Institute awarded Yale University $684,252 on June 2, 2026, under the Cancer Biology Research program (CFDA 93.396) to investigate the functions and mechanisms of innate lymphoid cells type 2 (ILC2s) in trained immunity. The research examines how ILC2s in bone marrow establish and sustain trained immunity—an epigenetic memory process in hematopoietic stem and progenitor cells that produces robust immune responses to subsequent inflammatory...
- The National Cancer Institute awarded Yale University $610,637 in project grant funding on April 1, 2026, under the Cancer Treatment Research program (CFDA 93.395) to engineer and optimize drug delivery platforms for locoregional treatment of advanced melanoma. Yale will develop bioadhesive and non-adhesive biodegradable nanoparticles engineered to deliver cytotoxic and immune conditioning agents selectively to tumor cells, the tumor microenvironment, and tumor-draining lymph nodes. The research...
- The National Cancer Institute awarded The Leland Stanford Junior University $143,278 under the Cancer Research Manpower program (CFDA 93.398) on January 1, 2026, to support research investigating evolutionary antagonism between tumors and lymphocytes. The recipient will conduct analyses of clonal diversity in metastatic cancer cells using viral integration site mapping across nine rounds of in vivo selection, perform single-cell transcriptomics to profile phenotypic diversity in relation to...
The National Cancer Institute awarded Yale University $100,228 on December 15, 2026, under the Cancer Research Manpower program (CFDA 93.398) to conduct observational studies on immune checkpoint inhibitor utilization, outcomes, and costs in advanced non-small cell lung cancer patients with preexisting autoimmune diseases. The research generates population-based evidence through three aims using real-world insurance claims data. Aim 1 analyzes MarketScan research databases to evaluate the association between autoimmune disease status and immunosuppressant use on immune checkpoint inhibitor utilization in patients with newly diagnosed advanced lung cancer across all ages. Aims 2 and 3 use SEER-Medicare data to estimate survival differences and compare immune-related adverse event costs, cancer treatment costs, and total healthcare costs between patients with and without preexisting autoimmune diseases in the over-65 population. The study addresses a critical evidence gap, as individuals with autoimmune diseases have been largely excluded from clinical trials despite the expanding use of immune checkpoint inhibitors in advanced lung cancer treatment. Yale University serves as the recipient with place of performance in New Haven, Connecticut. The period of performance runs from December 15, 2026, through July 15, 2028. The Cancer Research Manpower program supports biomedical training opportunities for individuals pursuing careers in basic, clinical, and prevention research important to the National Cancer Program.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $50.1k | 6/16/26 | ||
| Not listed | $0 | 6/16/26 | ||
| Not listed | $50.1k | 6/16/26 |