Project Grant F30CA306319
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded Columbia University's Health Sciences Division a Project Grant of $102,984 under the Cancer Research Manpower program (CFDA 93.398) to support research training and investigation into brain metastasis organotropism. The award, issued on December 25, 2025, with a completion date of June 30, 2028, funds a research initiative titled "Spatiotemporal Resolution of Niche and Genomic Co-Evolution in Brain-Metastatic...
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded Columbia University's Health Sciences Division a Project Grant of $151,263 under the Cancer Research Manpower program (CFDA 93.398) to support a two-year research initiative from September 1, 2025, through August 31, 2027. The project, titled "Understanding Paracrine Interactions Induced by Morphogens in PDAC," focuses on elucidating mechanisms of tumor microenvironment immunosuppression in pancreatic...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded a $223,176 Project Grant under the Cancer Research Manpower program (CFDA 93.398) to Duke University on September 10, 2025, with a completion date of April 30, 2028. This F32 postdoctoral fellowship award supports research investigating the role of SMARCAL1 (an annealing helicase) depletion in enhancing immunogenicity within Alternative Lengthening of Telomeres (ALT)-positive high-grade gliomas. The research addresses a...
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded a Project Grant of $205,404 to The Trustees of Columbia University in the City of New York (Health Sciences Division) under the Cancer Research Manpower program (CFDA 93.398), effective September 6, 2025, with completion targeted for March 6, 2029. The award supports mechanistic and functional research investigating the impact of genomic variants on T cell anti-tumor activity, with the objective of enhancing the...
- Federal Project Grant Award Summary New York University School of Medicine received a $315,246 Project Grant from the National Cancer Institute under the Cancer Research Manpower program (CFDA 93.398) effective August 1, 2025 through July 31, 2030. The award funds a research project titled "Breaking Cytokine Loops in Lung Adenocarcinoma," which investigates the molecular mechanisms underlying poor immunotherapy responses in patients with LKB1 (liver kinase B1)-mutant lung...
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded a Project Grant totaling $189,648 (awarded April 1, 2025; completion March 31, 2028) under the Cancer Research Manpower program (CFDA 93.398) to the University of Miami's Office of Research Administration—School of Medicine Division. This award supports a three-year biomedical research project investigating the mechanisms of mitochondrial biogenesis in T cell immunity, with particular focus on understanding how T...
- Federal Grant Award Summary Duke University's Office of Research Administration received a Project Grant award of $135,993 from the National Cancer Institute (NCI) under the Cancer Research Manpower program (CFDA 93.398), effective December 1, 2025, with an ultimate completion date of May 31, 2027. This award supports research training and investigator-led biomedical research aimed at developing cancer research workforce capabilities in areas relevant to the National Cancer Program. The...
- Federal Project Grant Summary The National Cancer Institute (NCI) awarded Sloan-Kettering Institute for Cancer Research a Project Grant of $292,028 under the Cancer Research Manpower program (CFDA 93.398) effective August 1, 2025, through July 31, 2030. This five-year research initiative investigates genome instability mechanisms associated with focal oncogene amplification (OA) and develops therapeutic strategies to address treatment-resistant cancers. The project employs advanced genomic...
- Federal Grant Award Summary Baylor College of Medicine received a $147,486 Project Grant from the National Cancer Institute under the Cancer Research Manpower program (CFDA 93.398) effective December 1, 2025, through April 20, 2027. The award supports research and development of RECON (Recombinant Element Control), a novel immune tolerization strategy designed to investigate the relationship between oncogene pathogenicity and immunogenicity in early-stage cancer development. RECON enables...
- Federal Grant Award Summary Dana-Farber Cancer Institute, Inc. received a $151,040 Project Grant award from the National Cancer Institute under the Cancer Research Manpower program (CFDA 93.398), effective January 16, 2026 through July 31, 2028. This award supports research training and investigator development focused on interrogating the role of Interferon Gamma (IFNG) in promoting metastasis and immune evasion in triple negative breast cancer (TNBC). The grant funds a structured research...
The National Cancer Institute (NCI) awarded Columbia University's Health Sciences Division a Project Grant totaling $102,984 under the Cancer Research Manpower program (CFDA 93.398) on January 17, 2026, with completion targeted for July 31, 2028. This award supports research training and investigation into a novel role of focal adhesion kinase (FAK) in modulating immunity during metastatic reactivation and progression in cancer patients. The research integrates in vivo genetic perturbation screening, RNA-sequencing analysis, and conditional mouse models to elucidate mechanisms by which FAK promotes metastatic reactivation and immune evasion by suppressing the STING (stimulator of interferon genes) cascade and T cell function. The research deliverables include mechanistic characterization of FAK's interaction with interferon regulatory factor 3 (IRF3) and validation of FAK as both necessary and sufficient for ablating STING-dependent immune outputs. The project aims to advance understanding of dormancy-to-reactivation transitions in metastatic disease, particularly in breast cancer and melanoma, through genetic validation experiments and exploration of FAK-targeting approaches including shRNA depletion and proteolysis-targeting chimera (PROTAC) methodologies. These findings are intended to inform novel therapeutic strategies for preventing metastatic relapse, the dominant cause of cancer-related mortality.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $0 | 7/17/25 | ||
| Not listed | $51.5k | 7/17/25 | ||
| Not listed | $51.5k | 7/17/25 |