This Project Grant award, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research to investigate the spatiotemporal regulation of epigenetic silencing by macromolecular interactions. The $1,271,250 award, effective from August 1, 2024 to May 31, 2029, will be performed by Weill Medical College of Cornell University in New York City. The research aims to elucidate how a critical histone...
This $148,568 federal Project Grant awarded by the National Institute of General Medical Sciences (NIGMS) under CFDA 93.859 Biomedical Research and Research Training Program will support research to elucidate the role of chromatin structures in genomic imprinting. The project, led by Harvard University, aims to investigate the regulatory mechanisms and functional implications of allele-specific chromatin structures in the regulation of the MEST-COPG2 imprinted domain, which is associated with...
This Project Grant award from the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310) provides $1,507,500.00 to Yale University to conduct research on the regulatory mechanisms by which the genome encodes non-genetic heterogeneity in cell systems. The project aims to identify transcription factor pairs that drive transcriptional heterogeneity, determine heritable memory loci capable of transmitting non-genetic heterogeneity across...
This $196,673 federal Project Grant award, funded by the National Science Foundation's (NSF) Mathematical and Physical Sciences (CFDA 47.049) program, supports collaborative research at Yale University to develop a predictive framework for understanding how the physical microenvironment influences 3D genome organization and gene expression. The project will integrate super-resolution microscopy, genomics, biophysical modeling, and machine learning to decode the relationship between the...
The National Institutes of Health (NIH) Office of the Director awarded $2,833,200 under the Trans-NIH Research Support program (CFDA 93.310) to Stanford University from September 1, 2022 to August 31, 2025. This Project Grant will support research exploring the structural flexibility of nucleosomes and its role in epigenetic regulation. The grantee will develop conformation-specific nanobodies to probe alternative states of nucleosomes using NMR, HDX-MS, and cryo-EM techniques. They will also...
This Project Grant award from the National Institutes of Health (NIH) under the Trans-NIH Research Support program (CFDA 93.310) supports research to visualize the mechanisms at the intersection of chromatin, transcription, and epigenetics. The $1,525,500 award to Harvard Medical School aims to develop a combinatorial biochemical and structural approach called "Visual Biochemistry" that uses a fully reconstituted chromatin transcription system and time-resolved single-particle...
This $427,571 federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports research at the University of Colorado-Denver to investigate the regulation of genome access and chromatin states, and how these factors determine cellular identity and gene expression patterns across the cell cycle. The research aims to develop new time-resolved structural epigenomic approaches to uncover previously...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) provides $2,720,800.00 in funding to Brigham & Women's Hospital Inc. over a period of 5 years, from July 5, 2024 to May 31, 2029. The award supports research focused on understanding the epigenetic regulation of transcriptional programming, with a particular emphasis on investigating the dynamic competition between Polycomb (PcG) and...
Yale University was awarded a $3,015,000 Project Grant from the Department of Health and Human Services National Institutes of Health Office of the Director under the Trans-NIH Research Support program (CFDA 93.310) for the period of September 15, 2022 through August 31, 2025. The grant will support research to develop a controllable and scalable in vitro model for studying human embryonic patterning and germ layer differentiation using human pluripotent stem cells and bioengineering...
This two-year, $1,204,512 National Science Foundation project grant supports research into the robustness and adaptability of the dynamic epigenome through a multiscale approach. Funded under the Biological Sciences program (CFDA 47.074), the award to Brandeis University involves investigating the fundamental rules that guide adaptive epigenetic changes in cells without alterations to the genetic blueprint. The research utilizes high-resolution imaging, microfluidics, and automated culture...