Project Grant DP2OD038783
- The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $1 Project Grant to the Mayo Clinic under the Oral Diseases and Disorders Research (CFDA 93.121) program. The grant, titled "COMMON FUND GENE UTILITY COMPENDIUM: A SYSTEMS BIOLOGY RESOURCE TO EXPLORE TISSUE-SPECIFIC FUNCTIONAL GENES AND DRUGGABLE GENOMES," aims to leverage NIH Common Fund datasets to identify tissue-specific druggable functional genes (TS-DFGs) that play critical roles in diseases like liver...
- This federal Project Grant award of $310,500.00 was provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121) to Virginia Commonwealth University. The funding supports a comparative experimental evolution study of gene essentiality in the oral bacteria Streptococcus sanguinis and S. mutans. The project aims to investigate the similarities and differences in essential genes between these two species, which...
- The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $673,091 Project Grant under the Oral Diseases and Disorders Research (CFDA 93.121) federal grant program to the University of Pittsburgh. The grant, which runs from August 14, 2025 to May 31, 2028, aims to advance the genomics knowledge base for oral diseases, focusing on dental caries and periodontitis. Key activities include performing the largest genome-wide association scans of these conditions, developing...
- This Project Grant award, identified as R03OD038393, was provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121). The $1 award will fund the development of a machine learning tool using Visible Neural Networks (VNN) to enhance the explanatory power of knowledge graphs derived from data in the Common Fund Data Ecosystem (CFDE) for translating genome-wide association study (GWAS) results into actionable...
- This Project Grant award, with a total funding of $222,211, was provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research (CFDA 93.121) federal grant program. The award supports research to understand how the chromatin modifiers PRDM3 and PRDM16 epigenetically control gene expression during craniofacial development. The project aims to define the molecular mechanisms regulating Wnt/β-catenin signaling in chondrocytes, identify...
- This $431,750 federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121) supports research to decipher the mechanisms by which two proteins, AAFLP-1 and AADCUB, regulate the production of exopolysaccharide (PNAG) in the oral bacterium Aggregatibacter actinomycetemcomitans. The research aims to investigate how these two proteins, which are unique to A. actinomycetemcomitans, independently...
- This federal Project Grant award of $1,638,033, provided by the National Institutes of Health (NIH) under the Biomedical Research and Research Training Program (CFDA 93.859), supports the development of a CRISPR-free mammalian recombineering system at the Scripps Research Institute. The project aims to characterize and optimize a bacterial recombinase system for efficiently conducting large-scale DNA insertions, deletions, and substitutions in mammalian cells without inducing cytotoxic...
- This federal Project Grant award of $600,029.00, funded by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), supports research to investigate the mechanisms by which dysregulation of the Ras/MAPK signaling pathway leads to craniofacial and dental abnormalities in Rasopathy syndromes. The awardee, Cedars-Sinai Medical Center, will use a combination of comparative morphometrics, transcriptomic, proteomic, and...
- This $295,856 Project Grant awarded by the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research federal grant program (CFDA 93.121), aims to identify rare genetic variants associated with orofacial clefts (OFCs). The two key objectives are: (1) identifying craniofacial genes with rare deleterious variants, and (2) identifying craniofacial enhancers with rare deleterious variants. By pinpointing these rare variants, the project seeks to...
- This federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), will support research to "Uncover Incomplete Penetrance Genes in Congenital Heart Disease by Integrative Analysis of Common Fund Data." The $1 award, made on June 10, 2025, will be performed by the Research Institute at Nationwide Children's Hospital in Ohio. The project aims to quantify the role of incomplete...
This federal Project Grant award for $1 was provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research (CFDA 93.121) program. The grant supports research to establish generalizable genome editing strategies that could be broadly applicable to treat hundreds of rare disease-causing genetic variants. The proposed work will address rare loss-of-function alleles and rare gain-of-function alleles, and will be studied in the context of specific genetic disorders like Marfan's syndrome and Charcot-Marie-Tooth disease. The project aims to develop safer and more effective delivery of genome editors using adeno-associated viral (AAV) vectors, with the ultimate goal of bringing the benefits of genome editing to patients with rare genetic diseases. The award was made to The Johns Hopkins University, a leading federal research institution, and has an ultimate completion date of August 31, 2028.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1 | 9/18/25 |