Project Grant DP2NS148060
- The Project Grant award, valued at $384,999 and provided by the National Institutes of Health (NIH) under the Trans-NIH Research Support program (CFDA 93.310), supports a research project conducted by The Leland Stanford Junior University (Stanford University). The project aims to address significant challenges in understanding RNA structure and its critical biological roles through a three-pronged approach: Developing computational tools, including an RNA sequence database (RNAMASS) and a novel...
- The federal Project Grant award of $673,600.00 from the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) aims to develop an RNA-based sensor that can detect changes in both mRNA and miRNA within living cells and mouse models. The objective is to create a programmable, synthetic biology tool that can identify diseased cells based on their RNA profiles and trigger...
- This $337,088 Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), aims to develop a versatile RNA delivery platform tailored for the central nervous system (CNS). The key products and services to be delivered through this funding include: The project seeks to establish an RNA delivery system with three core capabilities: high-efficiency RNA delivery, precise cell-specific targeting, and...
- This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program provides $310,834 to Clemson University to develop a nanoparticle-based platform for targeted, non-invasive delivery of therapeutics to the peripheral nervous system. The goal is to improve treatments for peripheral nerve injuries and diseases by overcoming the blood-nerve barrier that...
- This $375,134 Project Grant award from the National Cancer Institute (CFDA 93.395 - Cancer Treatment Research) supports research to develop a novel approach for reducing the off-target accumulation of chemotherapeutic nanomedicines. The key objectives are to characterize an innate immune response that can be leveraged to limit nanoparticle deposition in healthy tissues, thereby enhancing delivery to tumors and improving the efficacy of chemotherapy. The 5-year project, starting on March 1, 2025,...
- This federal Project Grant award for $390,000.00 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports the development of new tools for high-throughput characterization of extracellular RNA, DNA, and vesicles in bodily fluids. The primary objectives are to: 1) develop methods to reliably control for technical variability, RNA degradation, and complexity in cell-free RNA (cfRNA) analysis, including...
- This Project Grant award of $1,000,000, awarded by the Defense Health Agency under the Military Medical Research and Development program (CFDA 12.420), supports research by Brigham & Women's Hospital to develop a precision nonviral brain delivery system for CD33-targeting siRNA to treat Alzheimer's disease. The research, conducted in collaboration with Massachusetts General Hospital, aims to characterize novel nanoparticles for efficient delivery of CD33 siRNA to microglia in the brain,...
- This federal Project Grant award of $459,250.00, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research to develop a systematic approach for detecting regulatory RNAs and their functional motifs based on RNA-protein interactions. The key research objectives include: Investigating whether RNA regulates the genomic occupancies of chromatin-associated proteins (CAPs). Employing an...
- This Project Grant award from the National Cancer Institute (CFDA 93.398 Cancer Research Manpower) provides $122,577 to Trustees of Boston University for the development and characterization of self-amplifying RNA lipid nanoparticles. The goal is to create a platform that can sustainably and simultaneously deliver multiple immunostimulatory and gene therapy payloads directly to solid tumors, which account for nearly 90% of adult cancers and are difficult to treat effectively. The project aims to...
- The federal Project Grant award of $1,440,000.00 from the Department of Health and Human Services National Institutes of Health (NIH) Trans-NIH Research Support program (CFDA 93.310), awarded to Northwestern University on August 1, 2025, aims to develop a transformational approach to reprogram brain cells and enhance their resilience against a broad array of neurodevelopmental diseases. The project, titled "Perinatal Brain Therapeutics: A High Throughput Biology Approach to Build Next...
This $1,323,950 Project Grant was awarded on August 1, 2025 by the Department of Health and Human Services' National Institutes of Health (NIH) under the Trans-NIH Research Support program (CFDA 93.310). The grant was awarded to Clemson University to support research focused on developing nanoparticle-based delivery methods to enable the targeted transport of RNA-based therapeutics across the blood-brain barrier. The overarching goals are to 1) increase the stability of RNA in vivo, 2) control the timing of RNA release and protein translation, and 3) enable the delivery of RNA-based therapeutics into the brain. This high-risk, high-reward research aims to address key translational challenges and extend the use of RNA therapies to tissues that are difficult to reach using traditional polymer-based nanoparticles. The award has a performance period running through July 31, 2028.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.3m | 7/31/25 |