This Project Grant award from the National Institute of Mental Health (CFDA 93.242 - Mental Health Research Grants) provides $295,768 to The Washington University in St. Louis to conduct research on the evolutionary expansion and transcriptional correlates of the human cerebral cortex. The research will leverage state-of-the-art neuroimaging and single-cell transcriptomics to generate more accurate maps of cortical expansion in humans compared to macaques, and to investigate whether this...
The National Institutes of Health Office of the Director awarded The Trustees of Princeton University a $2,877,560 project grant under the Trans-NIH Research Support program (CFDA 93.310) to build a systematic, comprehensive mammalian cell fate map from September 1, 2022 to August 31, 2025. Leveraging single-cell RNA sequencing and CRISPR-Cas9 genome editing, Princeton University will establish an evolving lineage tracing platform capable of recording mammalian differentiation processes at...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program, provides $270,434 to The Trustees of Princeton University to investigate the role of spatiotemporal regulation of mRNA in neuronal remodeling during morphogenesis. The research will leverage Drosophila mushroom body and dendritic arborization neurons as models to...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program, will fund research to understand human brain development and the origins of neurodevelopmental diseases. The $1,008,977 award, with a performance period from December 2024 to November 2032, will support the study of primary human brain tissue and human stem cell-derived in...
This $679,072 Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) aims to establish a platform to accurately recapitulate and perturb cortical development and morphogenesis in vitro. The key objectives are to: 1) Develop bioengineering methods to generate organoids that accurately model the developing human forebrain, including the cortical hem, choroid plexus, and layered cortex; and 2) Establish a high-throughput...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) grant program, provides $606,548.00 to the University of Pittsburgh to develop a new recording modality called "mesoscopic electrophysiology" for non-human primate brain research. The goal is to create a 3D grid of 1,920 implanted electrodes that can record brain activity with high...
This Project Grant from the National Science Foundation Division of Behavioral and Cognitive Sciences provides $473,296 to the University of Massachusetts Amherst under the Social, Behavioral, and Economic Sciences federal grant program (CFDA 47.075) from June 1, 2022 to May 31, 2025. The award supports research examining the evolution of metabolism in the primate brain at the cellular level. Investigators will use advanced techniques to transform human and non-human primate cells into neurons...
The National Institutes of Health (NIH) Office of the Director awarded a $1,271,280 Project Grant under the Trans-NIH Research Support program (CFDA 93.310) to the Allen Institute, a non-profit research organization in Seattle, WA. The funding will support the development of two "exa-scale tissue readout" platforms to enable new types of molecular interrogation and mapping of neural circuits across entire brains. The first platform will map individual proteins at molecular...
The National Institutes of Health (NIH) Office of the Director awarded a $1,345,424 Project Grant under the Trans-NIH Research Support program (CFDA 93.310) to the Regents of the University of Michigan. The award supports the development of a "temporally scalable recording of brain-wide single-cell physiology" technology. This innovative system aims to enable long-term, brain-wide monitoring of neural activity and gene expression in individual cells, without external interfaces. Key...
This Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) will support research to elucidate the regulatory mechanisms underlying cell fate specification in the developing human cortex. The $682,470 award, spanning from August 2024 to May 2029, will enable investigators at the University of California, Los Angeles (UCLA) to leverage single-cell sequencing datasets and CRISPR-based screens to identify novel...