This federal Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), aims to establish a platform for accurately recapitulating and perturbing cortical development and morphogenesis in vitro. The $679,072 award to President and Fellows of Harvard College, spanning from November 2024 to October 2029, will develop and integrate novel technologies from stem cell biology, bioengineering, and genomics to generate organoid models that accurately represent the developing human forebrain. The project seeks to create a robust platform to perform high-throughput genetic perturbations and elucidate the mechanisms underlying human brain development and disease. This research is expected to provide the scientific community with an improved understanding of cortical patterning, morphogenesis, and the genetic underpinnings of these critical developmental processes.