Project Grant DP2GM159178
Award Date
9/5/24
Completion Date
8/31/27
Dollars Obligated
$1.5M
Funding Federal Agency
Office of the Director
Awarding Federal Agency
National Institute of General Medical Sciences
Federal Grant Program
93.310
Assistance Type
Project Grant
Place of Performance
Dallas, TX 75390, USA
Similar Awards
The University of Texas Southwestern Medical Center, a component of the University of Texas System, was awarded a $1,437,358 Project Grant from the National Institutes of Health (NIH) under the Trans-NIH Research Support (CFDA 93.310) program. The grant, awarded on September 22, 2023, aims to develop novel optogenetic technologies to enable precise spatial and temporal control of tumor formation in genetically engineered murine models. This capability will allow researchers to investigate how...
This $544,475 Project Grant award from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) aims to develop an in vitro cancer metastasis model system using decellularized organ-specific tissue (biomatrices) to study organ-specific cancer metastasis. The University of Texas Southwestern Medical Center, the awardee, hypothesizes that the biomatrices can recapitulate the organ microenvironment and enable the growth of organ-specific tumor colonies, which can be used to investigate...
This Project Grant award from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) provides $398,282 to the University of Houston System to conduct research on how metabolism shapes the survival of persister cells in mammalian cell populations. The central hypothesis is that persister cells, which are a small fraction of quiescent cells in a tumor that exhibit temporary drug tolerance, have a transient metabolic state characterized by increased oxidative phosphorylation and...
This $521,579 Project Grant award, provided by the National Cancer Institute (NCI) under the Cancer Biology Research program (CFDA 93.396), supports research to identify critical regulators controlling clear cell renal cell carcinoma (CCRCC) lung metastasis. The University of Texas Southwestern Medical Center, the awardee, will conduct a genome-wide CRISPR screen to characterize the role of the hepatic leukemia factor (HLF) in CCRCC lung metastasis and examine the underlying molecular...
This Project Grant award from the National Cancer Institute (CFDA 93.396 Cancer Biology Research) supports research to understand how cancer stem cells can transfer their mitochondria to macrophages, and how this mitochondrial transfer can reprogram the macrophages to support cancer growth and spread. The $161,794 award to Texas Tech University System will test the reproducibility of this mitochondrial transfer process across different cancer types, and determine if it is an active or passive...
This Project Grant award from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) provides $676,584.00 to The University of Texas MD Anderson Cancer Center to conduct research on the co-evolution of cancer subclones and their tumor microenvironment in metastatic triple-negative breast cancer (MTNBC). The overarching goal is to expand the fundamental understanding of MTNBC metastasis by investigating the genomic and transcriptomic evolution of primary tumor cells and their...
This $369,868 Project Grant award from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) supports research to investigate the functional role of mitochondrial transfer from nerves to breast cancer cells, and how this process impacts cancer metastasis and the generation of cancer stem cells. The project aims to use innovative lineage-tracing techniques to quantify the contribution of nerve-to-cancer mitochondrial transfer to the breast cancer metastasis cascade, and evaluate...
This Project Grant award from the National Cancer Institute (CFDA 93.398 Cancer Research Manpower) provides $140,130 to The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH), to elucidate the role of thiol reductive stress in lung cancer growth and metastasis. The award supports research investigating how activation of the NRF2 transcriptional regulator disrupts the NADH/NAD+ equilibrium, inducing reductive stress that blocks mitochondrial function and inhibits...
This Project Grant award from the National Cancer Institute (CFDA 93.395 - Cancer Treatment Research) to The University of Texas Southwestern Medical Center (UT Southwestern) supports research into mechanisms of therapeutic resistance in cancer. The $449,196 award, which runs from April 1, 2025 to March 31, 2030, focuses on investigating how receptor tyrosine kinase (RTK) inhibition triggers rapid sumoylation of RTKs, leading to adaptative responses that drive secondary resistance to targeted...
This Project Grant award, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research into the physiology of oxidative stress in bacteria. The total funding amount is $761,271.00, awarded from July 1, 2025 through June 30, 2030. The research aims to detail the threats that oxygen poses to bacteria, the defensive mechanisms they have evolved, and the situations in which oxidative stress...