This NSF Biological Sciences (CFDA 47.074) Project Grant award of $600,000 to Emory University will investigate how microbiome communities, which are communities of bacteria and other microbes that live in and on organisms, can resist change and transition to alternate states. The project will use the nematode worm Caenorhabditis elegans as a model host to better define the stability and properties of alternate microbiome states, as well as how factors like antibiotic treatment and host...
This $1,132,500 federal Project Grant award was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) to The Medical University of South Carolina. The grant, running from September 1, 2024 to June 30, 2029, will fund research to unravel the complex interactions between gut microbiota and intestinal mucus, a critical protective barrier. The research aims to elucidate how gut bacteria respond to and...
The National Institute of General Medical Sciences (NIGMS) awarded a $1,106,322 Project Grant (CFDA 93.859 Biomedical Research and Research Training) to the University of Oregon (UO) on July 15, 2024. This grant supports a 5-year research program to investigate how the host nutrient environment drives bacteria to adopt recalcitrant physiological states, such as slow growth and biofilm formation, that enable chronic infections and antibiotic resistance. The research integrates techniques like...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) provides $395,701 to the University of Texas at Austin to conduct research on the molecular bases of interbacterial and bacterial-host interactions in microbial communities. The key objectives are to: 1) understand how interbacterial competitive interactions affect microbiome composition and host health, 2) investigate how...
The National Institute of General Medical Sciences (NIGMS) awarded a 5-year, $1,140,912 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to the University of North Carolina at Chapel Hill. The project aims to understand the co-evolutionary dynamics between the immune system and beneficial microbiomes using the pea aphid as a model system. Key research activities include: Using functional and forward genetics, dual-RNA sequencing, and innate immunology...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under CFDA Program 93.859 Biomedical Research and Research Training, provides $396,510 to Brandeis University to conduct research on how archaeal microbes respond to mechanical stresses found in the human microbiome. The research aims to advance the mechanistic understanding of how microbial complexity in the microbiome influences human physiology. The project will employ a top-down, quantitative approach...
The National Institute of General Medical Sciences (NIGMS) awarded a $324,239 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to Ora Biomedical, Inc., a biotechnology company in Seattle, WA. The purpose of this Phase I Small Business Innovation Research (SBIR) grant is to develop "ELEGANTRY", a software and hardware infrastructure to improve rigor and reproducibility in invertebrate research using the model organism Caenorhabditis elegans (C....
This Project Grant award, valued at $133,246, was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The funding will support the development of flexible Bayesian statistical methods to gain a comprehensive understanding of microbial community dynamics using high-throughput sequencing data. The key objectives are to create a general method for inferring microbial community dynamics that vary with...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training Program (CFDA 93.859), provides $565,826 to Duke University to support research on the nutritional control of nematode development. The research aims to elucidate the signaling and gene regulatory mechanisms that enable nematodes (C. elegans) to adapt to fluctuations in nutrient availability, which has implications for understanding growth and quiescence...
This Project Grant award for $366,438, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859), will enable research to explore the fundamental mechanisms behind interactions between the human microbiome and the extracellular matrix (ECM). The University of Florida will develop in vitro and ex vivo models using biomaterials and tissue engineering strategies to address three key questions: 1) what...