Project Grant DP2DK136278
Award Date
9/19/22
Completion Date
8/31/25
Dollars Obligated
$2.7M
Funding Federal Agency
Office of the Director
Awarding Federal Agency
National Institute of Diabetes and Digestive and Kidney Diseases
Federal Grant Program
93.310
Assistance Type
Project Grant
Place of Performance
Pennsylvania, USA
Similar Awards
This Project Grant award from the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310) will provide $1,457,999.00 over a 3-year period from September 2024 to August 2027 to The Trustees of Princeton University to investigate how circadian clocks and feeding rhythms promote oscillations in gut microbiome composition and function, and how these microbial rhythms impact host physiology. The research will employ an interdisciplinary...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) provides $854,736 to support the development of robust statistical methods for analyzing longitudinal microbiome studies. The primary objectives are to create tools for addressing batch effects, identifying microbiome-exposure associations over time, characterizing microbiome interaction network dynamics, and improving data...
This Project Grant award from the National Institutes of Health (NIH) Office of the Director (CFDA 93.310 - Trans-NIH Research Support) provides $277,380 to the University of Colorado-Denver for a research project titled "CO-INFORMED PREDICTION OF MICROBIOME-METABOLOME INTERACTIONS THROUGH NOVEL TRANSFER LEARNING MODELS." The goal of the project is to develop novel statistical methods that can powerfully detect weak interactions between the gut microbiome and metabolome with limited...
The National Institute of General Medical Sciences (NIGMS) awarded a $403,750 Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to Duke University to conduct research aimed at "Unraveling Effects of Gut and Blood Microbial Signatures on Immune Phenotypes and Organ Dysfunction in Sepsis." The research project, spanning May 1, 2025 to February 28, 2030, will utilize a meta-systems approach to integrate gut microbiome profiling, metabolomics, intestinal...
This federal Project Grant award, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859), supports research to mechanistically understand how circadian and metabolic rhythms shape the functional maturation of fully differentiated cells. With total funding of $406,250 from June 2025 to April 2030, the research aims to: 1) Determine how circadian clock transcription factors program, synchronize, and entrain...
This federal Project Grant award of $361,454.00 from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports research to investigate the mechanisms underlying nutritional compensation in the circadian clock across fungal and mammalian systems. The key objectives are to: 1) define cellular effectors and metabolic variables that control circadian oscillations in fungi and test for conservation in human cells, and 2)...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859) provides $422,931 to characterize the role of specialized metabolites in mediating interactions within the human microbiome. The research aims to elucidate how metabolite-driven community dynamics influence antimicrobial susceptibility, with the goal of improving understanding of microbiome function and resilience. The 5-year...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research to investigate the regulatory mechanisms of mucus production in the large intestine. The $216,736 award to The Trustees of the University of Pennsylvania aims to identify how the host circadian clock and gut microbiome integrate temporal and microbial cues to control mucus...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) provides $220,340 to the Carnegie Institution of Washington, doing business as the Carnegie Institution for Science, to conduct research on how microbial communities coordinate growth and impact antibiotic sensitivities. The research aims to understand how cross-phylum signals, specifically the production of acetate by...
This $1,391,376 Project Grant award from the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310) supports a multidisciplinary research project to characterize the interactions between the gut microbiome and addiction. The primary objectives are to: 1) use metagenomics and metabolomics to identify psychostimulant-induced changes in gut microbial composition and metabolites, 2) apply pharmacological and microbiological techniques to...