Project Grant DP2CA311213
- This $452,250 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research at the University of Pittsburgh to investigate the role of nuclear speckles in coordinating protein quality control mechanisms. The overarching goal is to elucidate how nuclear speckles, traditionally viewed as facilitating mRNA processing and gene regulation, function as sensors of proteostatic stress and...
- This federal Project Grant award from the National Cancer Institute (NCI) under CFDA 93.396 (Cancer Biology Research) provides $182,755 to Cold Spring Harbor Laboratory (CSHL) to conduct research on genetic technology development for understanding lineage plasticity mechanisms in cancer. The award began on August 21, 2025 and is scheduled for completion on July 31, 2030. The key products and services to be delivered through this grant include: 1) developing a CRISPR screening methodology for...
- This federal Project Grant award of $459,250.00, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research to develop a systematic approach for detecting regulatory RNAs and their functional motifs based on RNA-protein interactions. The key research objectives include: Investigating whether RNA regulates the genomic occupancies of chromatin-associated proteins (CAPs). Employing an...
- This $1,220,400 Project Grant awarded by the National Science Foundation (NSF) Division of Molecular and Cellular Biosciences supports a collaborative research project between investigators in the U.S. and U.K. to better understand the regulatory mechanisms controlling mammalian gene expression. The project, funded through NSF's Biological Sciences program (CFDA 47.074), aims to define the roles of different DNA regulatory elements and how they work together to precisely control gene expression....
- This National Science Foundation (NSF) Project Grant award under the Biological Sciences program (CFDA 47.074) provides $522,131.00 to New York University (NYU) from August 1, 2023 to July 31, 2026. The funded research aims to understand the relationship between RNA sequence features and splicing outcomes, as well as the role that nuclear speckles play in RNA splicing decisions. The project will leverage high-throughput assays and interpretable machine learning to identify sequence-encoded...
- This Project Grant award from the National Institutes of Health (NIH) under the Trans-NIH Research Support program (CFDA 93.310) supports research to visualize the mechanisms at the intersection of chromatin, transcription, and epigenetics. The $1,525,500 award to Harvard Medical School aims to develop a combinatorial biochemical and structural approach called "Visual Biochemistry" that uses a fully reconstituted chromatin transcription system and time-resolved single-particle...
- This federal Project Grant award of $667,480.00 was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) to St. Jude Children's Research Hospital Inc. The award supports fundamental scientific research and advanced training focused on understanding the regulation of genome expression by chromatin and how mutations in chromatin proteins contribute to oncogenesis. The research aims to provide new insights...
- The National Science Foundation awarded a $2 million project grant to Cold Spring Harbor Laboratory to support research investigating how animals maintain correct gene expression timing during development at varying temperatures. Funded under the Biological Sciences program (CFDA 47.074), this four-year award beginning in July 2022 will enable the awardee to utilize microfluidic imaging technology to quantitatively study temporal patterning in the gene regulatory networks that control...
- This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) aims to investigate how the nuclear protein lamins regulate genome organization and gene expression during development. The $335,000 award to the Carnegie Institution of Washington will be used to study the mechanisms by which lamins control 3D chromatin interactions and gene regulation in mouse embryonic stem cells and...
- This $292,727 Project Grant award from the National Institutes of Health (NIH) under the Trans-NIH Research Support program (CFDA 93.310) supports a research project by The Broad Institute, Inc. to discover novel regulators of 3D genome organization. The project aims to leverage large-scale genomic datasets to predict and experimentally validate new trans-acting factors that regulate chromatin interactions and genome architecture. By applying deep neural network models to in silico genetic...
The federal Project Grant award of $1,749,106 from the National Institutes of Health (NIH) Trans-NIH Research Support Program (CFDA 93.310) supports research at Cold Spring Harbor Laboratory (CSHL) to investigate the role of nuclear speckles in gene regulation. The research aims to identify new transcription factors that drive DNA-speckle association, determine the importance of this function for diseases like cancer and inflammation, and develop ways to inhibit it using chemical compounds. The project also examines how the structural states of nuclear speckles dynamically respond to extracellular signals and regulate expression of large gene neighborhoods. This 3-year project, with an end date of July 31, 2028, leverages CSHL's expertise in molecular biology, genetics, and computational biology to advance the mechanistic understanding of how nuclear speckles regulate gene expression, with potential implications for developing new therapeutic approaches across disease areas.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.7m | 8/4/25 |