Project Grant R21AI194167

Award Date 6/23/25
Completion Date 5/31/27
Dollars Obligated $404K
Federal Grant Program
93.855
Assistance Type
Project Grant
Place of Performance
Davis, CA, USA
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This Project Grant award, identified as R21AI194167, was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The $404,108 grant, awarded on June 23, 2025, will support research at the University of California, Davis to identify the key genetic and signaling pathways that enable Mycobacterium tuberculosis (MTB) to form antibiotic persister cells, which can survive prolonged exposure to lethal antibiotics. The goal is to gain insights that could lead to the development of "persistence inhibitors" to be used in combination with traditional antibiotics to more effectively eradicate MTB in patients. The research will utilize a combination of genetic and proteomic approaches to rigorously identify the core pathways contributing to MTB persister cell survival across multiple contexts. If successful, these findings could have significant implications for improving tuberculosis treatment.

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