The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $721,194 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to Florida State University (FSU). The purpose of this 5-year grant, which began on March 1, 2025, is to investigate the structural and functional roles of key protein complexes involved in the cell division process of Mycobacterium tuberculosis, the causative agent of tuberculosis. Specifically, the research will employ advanced solid-state and solution nuclear magnetic resonance (NMR) techniques, combined with molecular dynamics simulations, to characterize the interactions between the FtsQ, FtsZ, FtsB, and FtsL proteins that comprise the divisome machinery in M. tuberculosis. This work aims to provide critical insights into the cell division process, identify potential drug targets, and inform the development of more effective therapeutic strategies to address the global tuberculosis epidemic.
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