Racial equity in systems to treat opioid use disorder for everyone (restore): a pilot randomized controlled trial

Active Project Grant Awarded Last action

Award ID
DP1DA058978
Recipient
Awarding agency
Obligated
$4,214,000

Award facts

Assistance listing
93.279 Drug Use and Addiction Research Programs
Completion date 53% complete
Originally
Place of performance
San Diego, CA 92182, USA

Award details come from USAspending.gov.

Description

Abstract
I am a well-published, early stage medical sociologist applying for a nida-funded racial equity visionary award focused on the feasibility, acceptability, and preliminary efficacy of an innovative, mixed methods, community- engaged intervention targeting non-hispanic black (NHB) individuals with opioid use disorder (OUD). This study will apply my understanding of community needs and OUD, to test a novel intervention in a scalable setting, leveraging my role as a leader in this field to disseminate findings and improve treatment access nationwide. Opioid-related overdoses are increasing fastest in NHB individuals. In 2020, amid the covid-19 pandemic, NHB overdose deaths increased by 45%, nearly double the increase in non-hispanic whites (NHW). Disproportionate increases in overdoses correspond to racial inequities in OUD treatment access and utilization. An effective treatment, buprenorphine, is concentrated among communities with high percentages of nhws, higher income, and private insurance. Compared with NHW patients with OUD, NHB patients with OUD are 77% less likely to have an office visit that includes a buprenorphine prescription, despite similar prevalence of ouds. This structural problem is at the foundation of my proposed research. Research focused on developing and testing culturally effective, community grounded, and structurally competent OUD treatments with rigorous implementation assessments is urgently needed to intervene on structural barriers to OUD treatment that operate in settings in which NHB individuals seek healthcare. Significant federal funding has expanded access to OUD treatment services in community health centers (chcs) that provide care to underserved populations and areas but barriers to accessing care remain in nhbs. I propose to prepare for a fully powered clinical trial by testing whether a buprenorphine treatment intervention protocol (racial equity in systems to treat opioid use disorder for everyone-restore) that targets structural barriers to OUD treatment for NHB individuals is feasible in the context of chcs. Restore draws upon concepts of structural competency, peer navigation, and culturally grounded OUD education for both patients and providers. Community engagement will be continuous, exemplified by the use of peer navigators to connect patients to care. Restore will be based in southern california-an epicenter of the nation's opioid crisis. Project phases, guided by cutting edge implementation science, include 1) a qualitative investigation into provider and patient barriers to and facilitators of chcs' provision of buprenorphine specifically to NHB individuals with OUD; 2) the operationalization of restore into routine care, using preliminary findings from phase i; and 3) a pilot stepped-wedge randomized controlled trial to test the feasibility, acceptability, and preliminary efficacy of restore, as well as the protocols, procedures and training in chcs. This study has the potential to improve effective treatment rates in 4 clinics and provide an evidence-based intervention to be tested at scale across multiple states. Improvements in local treatments, designed to reach nhbs, will greatly reduce the current increase in overdose disparities.

Transactions

Action Obligated Date
Amendment $1,053,500
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Amendment RE-engineering systems to treat opioid use disorder for everyone (restore): a pilot randomized controlled trial - i am a well-published, early stage medical… $0
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Amendment RE-engineering systems to treat opioid use disorder for everyone (restore): a pilot randomized controlled trial - i am a well-published, early stage medical… $0
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Amendment RE-engineering systems to treat opioid use disorder for everyone (restore): a pilot randomized controlled trial - i am a well-published, early stage medical… $0
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Amendment RE-engineering systems to treat opioid use disorder for everyone (restore): a pilot randomized controlled trial - i am a well-published, early stage medical… $0
Amendment $1,053,500
Amendment $1,053,500
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Original award $1,053,500
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Subawards

Subrecipient Amount Awarded
William King, M.d., P.C. The RESTORE program is a community-academic research collaborative within the Division of Health Promotion and Behavioral Science in the School of Public Health… $161,865
University Of California, LOS Angeles UCLA PI, is a licensed clinical psychologist and board-certified sex therapist. She is a Professor Emerita in the Department of Psychiatry and Biobehavioral… $34,774
The Rand Corporation Throughout the 5-year study period, RAND PI will conduct the following work: • Provide input into FQHC and other stakeholder engagement • Assist with… $406,351

Quick answers

Who received award DP1DA058978?

DP1DA058978 was awarded to San Diego State University Foundation by National Institute on Drug Abuse (National Institutes of Health) on September 1, 2023.

How much is award DP1DA058978 worth?

$4,214,000 has been obligated on DP1DA058978.

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