Project Grant DESC0025928

This $300,000 Project Grant awarded by the National Science Foundation (NSF) Engineering program (CFDA 47.041) supports the development of a new optical microscopy technology called "Space-Time-Pulsed Engineered-Excitation for Diffraction-Free Imaging (SPEEDI)." The technology utilizes exotic space-time wave packets to enable high-resolution fluorescence imaging of deep brain tissue without the light scrambling issues of conventional microscopy. The research aims to advance imaging...

This federal Project Grant award from the National Science Foundation's Biological Sciences program (CFDA 47.074) supports the development of HOLOCON, a new imaging tool that combines three-dimensional holographic imaging and fluorescent microscopy. This tool will allow researchers to simultaneously visualize and quantify free-swimming bacteria and bacterial biofilms in three dimensions and in real-time at the single-cell level. The $307,738 award to Yale University aims to provide critical...

This $307,754 National Science Foundation Engineering Directorate project grant will fund the acquisition of a Nikon CSU-W1-SORA super-resolution spinning disk confocal microscope for Boston University. The microscope will enable new spatially resolved transcriptomics and multi-scale connectomics research techniques to study gene expression within cells and neural connectivity in brain networks. As a shared resource housed in BU's Photonics Center, the microscope is expected to serve nine...

The University of California, San Diego (UCSD) was awarded a $587,425 Project Grant from the National Science Foundation (NSF) Engineering program (CFDA 47.041) to develop the first dual-modality super-resolution microscopy system, termed Dual-Modality Localized Plasmonic Structured Illumination Microscopy (DM-LPSIM). This new imaging technology will enable simultaneous high-speed super-resolution fluorescence and label-free scattering imaging at the 50-nanometer scale. The DM-LPSIM system...

This federal Project Grant award of $551,957 from the National Science Foundation's (NSF) Integrative Activities program (CFDA 47.083) provides funding to the University of Scranton to acquire an Olympus Fluoview FV4000 inverted confocal microscope system. This microscope will be integrated into the university's upper-level biology courses and made accessible to faculty at other local universities to enhance research and training capabilities in multiple biological fields, including cellular...

The University of Michigan was awarded a $1.8 million project grant from the National Institutes of Health Office of the Director under the Research Infrastructure Programs federal grant program to purchase a Leica SP8 confocal microscope. The microscope will support over 30 investigators at the University engaged in diabetes, vision, and retinal research by replacing two aging microscopes in the university's shared imaging facility. The new microscope will provide high-speed resonant scanning...

This National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) Small Business Innovation Research (SBIR) Phase I project award of $274,998 to Magnify Biosciences Inc. aims to develop an automated "AutoMagnify" device that physically expands biological specimens up to 1,000 times in 3D while preserving spatial and molecular integrity. This advancement will enable conventional light microscopes to achieve nanoscale imaging resolution capabilities...

This Project Grant award from the National Science Foundation's Integrative Activities program (CFDA 47.083) provides $476,440 to the University of South Alabama to acquire a dual inverted selective plane illumination microscopy (diSPIM) light sheet system. The diSPIM system enables rapid, high-resolution imaging of large biological samples with minimal photodamage, allowing simultaneous measurement of intracellular signals and protein localization across complex model systems. This advanced...

This Project Grant award from the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) provides $260,183 to develop HOLOCON, a new 3D holographic imaging tool that can simultaneously observe and quantify free-swimming bacteria and bacterial biofilms at the single-cell level. The goal is to better understand how bacteria interact with biofilms and switch between swimming and non-swimming states, which is crucial for controlling harmful biofilms in industrial and medical...

This Project Grant award from the National Science Foundation (NSF) Integrative Activities program (CFDA 47.083) provides $466,187 to the University of Portland (UP) to acquire a spinning-disk confocal microscope. The microscope will enable enhanced cell and molecular biology research and undergraduate teaching and training at UP and Lewis & Clark College. The award supports research programs investigating biological mechanisms such as developmental asymmetry, cardiac development, and the...