Project Grant DESC0019680

This $1,000,000 Cooperative Agreement award from the National Science Foundation's (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) program aims to accelerate R&D in the pharmaceutical industry through the development of streamlined machine learning algorithms for small data applications in advanced manufacturing. The project, awarded to Sunthetics Inc., seeks to save time and resources by up to 95% in lead optimization and route scouting during pre-clinical drug development by...

Geometric Data Analytics Inc. received a $249,252 Project Grant award from the Department of Energy Office of Science on February 14, 2022 to develop cloud-based biological data preparation, tracking, and checking technologies for artificial intelligence applications. The grant was awarded under the Office of Science Financial Assistance Program (CFDA #81.049), which supports basic research to deliver scientific discoveries and tools that transform understanding of nature and advance U.S. energy...

This federal Project Grant award, valued at $596,920 and provided by the National Science Foundation (NSF) Engineering program (CFDA 47.041), aims to develop a mechanism-informed AI platform to optimize biomanufacturing processes for life-saving biopharmaceuticals. Led by Northeastern University, the project will leverage emerging sensing technologies to efficiently decode the fundamental mechanisms underlying complex biomanufacturing systems. The goal is to create a flexible and robust AI-based...

This Project Grant award from the National Science Foundation (NSF) under its Technology, Innovation, and Partnerships (TIP) program (CFDA 47.084) provides $275,000 to Tectaria Bio LLC to engineer cell lines with activated proteasomes for increased biomanufacturing efficiency. The project aims to test the feasibility and application of a novel technology to significantly increase the protein production capabilities of cell lines used in the manufacture of biologics, gene therapies, and vaccines....

This Project Grant award from the National Science Foundation's (NSF) Technology, Innovation, and Partnerships program (CFDA 47.084) provides $275,000 to Targeting Systems to develop a novel intramuscular gene delivery platform capable of sustained expression and endogenous secretion of bispecific natural killer cell engager (BIKE) therapeutics to treat solid tumors like hepatocellular carcinoma. The platform aims to deliver BIKEs in a less invasive manner than current immunotherapies,...

This National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) Project Grant award of $275,000 to Om Therapeutics Inc. will support the development of a system to enable the rapid, scalable, and cost-effective discovery of new medicines using machine learning. The project aims to encapsulate proteins and small molecules in millions of miniaturized compartments to screen for interactions that could identify novel drug candidates. The key innovations include...

The Biosyntheticmachines.com Inc. was awarded a $249,995 Project Grant from the Department of Energy Office of Science on February 21, 2023 to develop a computer environment supporting biosystem design guided by machine learning. The grant was awarded under the Office of Science Financial Assistance Program (CFDA 81.049), which supports scientific discoveries and tools to transform understanding of nature and advance U.S. energy and economic security. Specifically, this award will fund the...

This $252,906 National Science Foundation project grant supports the development of scalable manufacturing methods for peptide amphiphile molecules by Amphix Bio Inc. The goal is to advance a safer and more affordable alternative to recombinant proteins currently used in spinal fusion surgeries. Over 500,000 such surgeries are performed annually in the U.S. to treat back and neck pain. While peptide amphiphiles show promise for reducing biological dose needs and offering consistent outcomes,...

This National Science Foundation Project Grant of $255,995 supported Encapsulate Inc. to develop an automated biochip platform for personalized cancer screening under the NSF Technology, Innovation, and Partnerships program (CFDA 47.084). The award period was from May 15, 2022 to April 30, 2023. The platform will grow patient-derived cancer cells outside the body on biochips to screen them against chemotherapy drugs. This addresses the problem that over 70% of cancer patients undergo ineffective...

This $228,697 National Science Foundation award under the Engineering program (CFDA 47.041) will support the development of an optical biosensor technology to facilitate drug screening and validation efforts. Auctus Biologics, Inc. will utilize a proprietary temperature, pH, and chemically stable protein composed of two fragments that bind with antibody-like affinity and specificity. Over the one-year period ending January 2023, the company will establish the technology's suitability for...