Project Grant 83500001

This three-year, $3.13 million project grant from the National Institutes of Health's National Institute of Environmental Health Sciences will fund research at Michigan State University investigating the progression of non-alcoholic fatty liver disease. Specifically, the grant will test the hypothesis that activation of the aryl hydrocarbon receptor by environmental contaminants reprograms fatty acid metabolism, causing the accumulation of toxic lipid intermediates that contribute to...

This Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA), under the Alcohol Research Programs (CFDA 93.273) federal grant program, supports research to examine the role of non-parenchymal cells in driving the key features of alcohol-associated hepatitis (AAH) in a fully humanized mouse liver model. The $688,199 award, effective June 1, 2025 through February 28, 2030, will enable researchers at Yale University to investigate specific ligand-receptor...

This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $862,440 to the Fred Hutchinson Cancer Center in Seattle, WA to establish and validate a robust and low-cost liver humanized NSG-PIZ mouse model for the study of chronic hepatitis B virus (HBV) infection. The key objectives are to: 1) Evaluate the anti-HBV efficacy of HBV gene therapy in the liver-humanized mouse...

This federal Project Grant award of $822,643.00, awarded by the National Institute on Aging under the Aging Research program (CFDA 93.866), will fund a research project to investigate how chronic exposure to common environmental neurotoxicants like lead, cadmium, and arsenic impact brain aging and the risk of late-onset Alzheimer's disease (LOAD). The researchers at Boston University Medical Campus, the prime awardee, will use innovative mouse models developed by the Model-AD Consortium to study...

This Project Grant award from the National Cancer Institute (CFDA 93.394 - Cancer Detection and Diagnosis Research) provides $536,836 to The University of Texas MD Anderson Cancer Center to develop mathematical models and computational methodologies to optimize the delivery of a transarterial ablative therapy for treating hepatocellular carcinoma. The key objectives are to: Formulate mathematical models that capture the complex multiphase flow, heat transfer, and chemical reactions occurring...

This federal Project Grant award from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health (CFDA 93.113) program provides $900,804 to Lena Biosciences, Inc., a woman-owned small business, to develop an integrated microphysiological screening platform with "virtual human" models for assessing chemical toxicity. The goal is to create a cost-effective screening solution that incorporates human genetic diversity to better evaluate chemical risks...

This $157,667 Project Grant award from the Environmental Protection Agency (EPA) under the Science to Achieve Results (STAR) Research Program (CFDA 66.509) aims to develop a predicted reaction network using experimental and computational data to describe the environmental lifecycle of persistent biological transformation products (TPs) of chemicals. The key activities include integrating new approach methodologies, supplementing experimental data with computational techniques leveraging Carnegie...

This $599,416 project grant awarded by the National Institute of Environmental Health Sciences (NIEHS) under the CFDA 93.113 Environmental Health program aims to develop, test, and apply new statistical methods to address analytical challenges in environmental epidemiology research. The key products and services to be delivered include: Bayesian scalar-on-quantile-function regression models to estimate associations between population-level health outcomes and spatially-resolved exposure...

The federal Project Grant award R21AI178204, provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to investigate the role of the C/EBPβ transcription factor in sepsis-associated acute-on-chronic liver failure (ACLF). The $867,998 award, spanning from July 2024 to May 2026, aims to study the mechanisms by which endothelial dysfunction and dysregulated angiopoietin signaling lead to...

The National Institute of Environmental Health Sciences (NIEHS) awarded a 5-year, $605,550 Project Grant under the Environmental Health (CFDA 93.113) program to the University of Toledo Health Science Campus to study the developmental impacts of pyrethroid pesticide exposure using the prairie vole as an animal model. The research aims to determine the maximum safe dose of the pyrethroid insecticide deltamethrin during pregnancy and lactation by assessing dose-dependent changes in behaviors,...