This $421,047 Project Grant award from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health (CFDA 93.113) program supports research on the interaction between genetic and environmental risk factors for autism and other neurodevelopmental disorders. The principal investigator will use the prairie vole, a rodent species with complex social behaviors, to study how exposure to the pyrethroid pesticide deltamethrin during pregnancy and lactation impacts...
The National Institute of Environmental Health Sciences (NIEHS) awarded Purdue University a $1,968,864 Project Grant under the Environmental Health (CFDA 93.113) federal grant program. The goal of this 5-year research project is to evaluate and compare the neurotoxic impacts of exposure to various per- and polyfluoroalkyl substances (PFAS), including legacy chemicals like PFOA and replacement compounds like PFBA and GenX. The research will use zebrafish and human induced pluripotent stem cell...
This federal Project Grant award from the National Institute of Environmental Health Sciences (NIEHS), under the CFDA 93.113 Environmental Health program, is focused on investigating novel genetic variants that confer susceptibility to pesticide-induced Parkinson's disease. The total funding amount is $728,408 awarded over a period from January 2025 to November 2029. The key objectives of the project are to: 1) Evaluate the effects of gene up-regulation and down-regulation on markers of...
The University of California, San Diego (UCSD) has been awarded a $159,200 Project Grant from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health (CFDA 93.113) federal grant program. The project, titled "Redox Signaling During Neurodevelopment and Sensitivity to Oxidative Stress," aims to characterize the role of oxidation-reduction (redox) signaling in normal forebrain neurodevelopment in mice and its response to environmental exposures, such...
This Cooperative Agreement award from the National Institute of Environmental Health Sciences (NIEHS), part of the Environmental Health (CFDA 93.113) federal grant program, provides $398,838 to North Carolina State University (NC State) to investigate the neurodevelopmental effects of exposure to flame retardants. The key objectives are to: 1) Evaluate how developmental exposure to the flame retardant mixture Firemaster 550 impacts the density and gene expression of dopamine, oxytocin, and...
This Project Grant award from the National Institute of Environmental Health Sciences (NIEHS), under the Environmental Health (CFDA 93.113) program, aims to define the neurotoxic and neurodevelopmental health risks associated with exposure to per- and polyfluoroalkyl substances (PFAS). The $546,350 grant, awarded on January 13, 2025, will support a research study to investigate the mechanisms of PFAS uptake by neurons, the neurotoxic effects of PFAS exposure, and the impacts of PFAS on...
This Project Grant award of $411,847 from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health (CFDA 93.113) program will support research to determine whether exposure to the widely used insecticide imidacloprid (IMI) causes ovarian toxicity and female subfertility/infertility in a mouse model. The study aims to: 1) assess the extent to which IMI exposure leads to ovarian toxicity and female reproductive issues in vivo, and 2) identify molecular changes...
The National Institute of Environmental Health Sciences (NIEHS) awarded a $2,171,433 Project Grant (CFDA 93.113 - Environmental Health) to Yale University to conduct a study titled "Environmental Chemical Exposures and Biologic Markers for Cerebral Palsy (EXPOSE CP)". The 5-year study, running from May 2024 to February 2029, will investigate the potential impact of environmental toxicants like per- and polyfluoroalkyl substances (PFAS), polybrominated diphenyl ethers (PBDE), and...
This Project Grant award from the National Institute of Environmental Health Sciences (NIEHS), under the Environmental Health (CFDA 93.113) program, provides $574,042 to Vivoverse, LLC, a woman-owned small business in Austin, Texas, to develop high-content in vivo developmental neurotoxicity (DNT) testing using the C. elegans model organism. The project aims to establish a comprehensive DNT test battery that tracks neuronal, synaptic, and behavioral changes in C. elegans exposed to DNT toxicants...
This federal Project Grant award of $843,410 from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health (CFDA 93.113) program aims to establish the fruit fly, Drosophila melanogaster, as a model for assessing the neurodevelopmental impacts of air pollution, specifically diesel exhaust. The key objectives are to: Determine the effects of varying developmental stage and diesel exhaust dose exposures on neurodevelopmentally programmed behaviors and metabolic...
The National Institute of Environmental Health Sciences (NIEHS) awarded a $605,550 Project Grant under the Environmental Health (CFDA 93.113) program to the University of Toledo Health Science Campus Division for a study titled "Developmental Pyrethroid Exposure in the Prairie Vole as a Model of Environmental Risk for Autism." The project aims to explore the maximum safe developmental dose of the pyrethroid pesticide deltamethrin and its effects on neurodevelopmental outcomes in prairie voles, a rodent species with social behaviors relevant to autism spectrum disorder. Key objectives include assessing dose-dependent behavioral changes in controlled laboratory tests and natural outdoor enclosures, as well as evaluating multi-modal molecular effects in the brain's central circadian pacemaker. The 5-year project period runs from May 1, 2025 to February 28, 2030 and will provide critical insights into environmental risk factors and potential biomarkers for neurodevelopmental disorders.