Project Grant 2603156
- The National Science Foundation Division of Chemistry awarded the University of Washington $479,403 on August 15, 2026, under the Mathematical and Physical Sciences program (CFDA 47.049) to develop and optimize mass spectrometry methods for characterizing complex glycoproteins and their heterogeneous glycosylation states. The project will advance ion-ion reactions and tandem mass spectrometry instrumentation through combinations of collision-, electron-, and photon-based gas-phase activation,...
- The National Science Foundation Division of Chemistry awarded the University of Washington $429,336 on August 15, 2026, to develop residue-specific resolution hydrogen/deuterium exchange with mass spectrometry (HDX-MS), a bioanalytical technique for characterizing protein structure and binding interactions. The project, funded under the Mathematical and Physical Sciences program (CFDA 47.049), runs through July 31, 2029, and is performed in Seattle, Washington. Current HDX-MS methods operate...
- This Project Grant award from the National Science Foundation's (NSF) Division of Chemistry, under the Mathematical and Physical Sciences (CFDA 47.049) Federal Grant Program, provides $551,717 in funding to the University of Washington for a 3-year project period from August 1, 2024 to July 31, 2027. The project, led by Professor Frantisek Turecek, focuses on developing new chemical reactions for crosslinking biomolecular ions representing components of proteins and nucleic acids. The research...
- This Project Grant award from the National Science Foundation's Division of Chemistry (CFDA 47.049 - Mathematical and Physical Sciences) is providing $399,997 to the University of Washington to advance hydrogen/deuterium exchange mass spectrometry (HDX-MS) for studying protein structure and dynamics. The key objectives are to: 1) develop internal standards to improve the reproducibility of HDX-MS measurements, 2) create software tools for more robust analysis of HDX-MS data to better detect...
- The National Science Foundation (NSF) Division of Chemistry awarded a $710,000 Project Grant to Boise State University under the Mathematical and Physical Sciences program (CFDA 47.049) to acquire a high-resolution liquid chromatography-mass spectrometry (LC-MS) system. This system will enhance research infrastructure and enable new capabilities in proteomics and metabolomics research at the university. The grant will support graduate, undergraduate, and high school student training in modern...
- Grant Award Summary Washington State University, under the direction of Professor Brian H. Clowers, received a $485,838 Project Grant award from the National Science Foundation's Division of Chemistry (CFDA 47.049 – Mathematical and Physical Sciences) effective September 1, 2025, through August 31, 2028. The grant supports the development of a novel analytical platform for advancing chemical separations through multimodal ion chemistry and tandem ion mobility spectrometry. The research team will...
- The National Science Foundation (NSF) Division of Chemistry awarded a 3-year, $389,999 Project Grant to Florida State University (FSU) under the Mathematical and Physical Sciences program (CFDA 47.049) to develop new approaches to characterize the structural dynamics of proteins that play critical roles in chemical reactions within biological cells. The project, led by Dr. Christian Bleiholder, will combine and enhance the capabilities of tandem-ion mobility spectrometry coupled with mass...
- The National Science Foundation (NSF) Division of Chemistry awarded a $420,000 Project Grant to the Regents of the University of Michigan under the Mathematical and Physical Sciences program (CFDA 47.049) to develop new high-throughput technologies for characterizing the 3-dimensional structures of proteins and RNA. Specifically, the funding will support Professor Brandon Ruotolo and his research team in expanding the capabilities of Collision Induced Unfolding (CIU) - an approach that uses...
- The National Science Foundation Division of Chemistry awarded a $1,010,000 project grant to the University of Texas at Austin to develop innovative mass spectrometry methods for characterizing intact proteins through June 2025 under the Mathematical and Physical Sciences program (CFDA 47.049). Professor Jenny Brodbelt and her research group will apply ultraviolet photodissociation and other dynamic ion manipulation strategies to amplify structural and post-translational modification details...
- The National Science Foundation Division of Chemistry awarded $950,000 to the University of California, Berkeley under the Mathematical and Physical Sciences federal grant program (CFDA 47.049) to support research on the chemistry and physics of charged aqueous nanodrops and their applications in mass spectrometry. Professor Evan Williams and his group will investigate how the size and shape of electrospray ionization emitters affect initial droplet size and mass spectrometry performance. They...
The National Science Foundation Division of Chemistry awarded the University of Washington $588,303 on August 15, 2026, under the Mathematical and Physical Sciences program (CFDA 47.049) to develop computational methods and experimental techniques for ion mobility–mass spectrometry that advance the measurement of protein and molecular structures and dynamics. The research group will create fast computational methods for interpreting ion mobility–mass spectrometry measurements and introduce a new experimental method providing precise, independent control over measurement conditions to address standardization barriers across laboratories. The methods and software will be released as free, open-source resources for the research community, making sophisticated measurements possible on low-cost computers and comparable across institutions. In biotechnology applications, the tools could accelerate characterization of protein therapeutics, including antibody drugs, and support identification of small molecules that stabilize disease-related proteins for new medicine development. The project runs through July 31, 2029, with performance at the University of Washington in Seattle, Washington. The work will train two graduate students and at least one undergraduate researcher in chemical measurements and data science, and will expand and disseminate educational materials from a national mass spectrometry workshop to broaden access to training in measurement technology fundamentals.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $588.3k | 8/12/26 |