The National Science Foundation (NSF) Division of Chemistry awarded a 3-year, $389,999 Project Grant to Florida State University (FSU) under the Mathematical and Physical Sciences program (CFDA 47.049) to develop new approaches to characterize the structural dynamics of proteins that play critical roles in chemical reactions within biological cells. The project, led by Dr. Christian Bleiholder, will combine and enhance the capabilities of tandem-ion mobility spectrometry coupled with mass...
The National Science Foundation (NSF) Division of Chemistry awarded a $500,000 Project Grant titled "TOPICS IN PROTEIN AND RNA FOLDING AND DYNAMICS" to the University of Texas at Austin under the Mathematical and Physical Sciences program (CFDA 47.049). This 4-year grant will support Professor Devarajan Thirumalai's research on the computational modeling of protein and RNA interactions and dynamics. Key focus areas include developing new methods to simulate intrinsically disordered...
This National Science Foundation (NSF) Project Grant award, provided through the Mathematical and Physical Sciences program (CFDA 47.049), supports research led by Professor Kristina Hakansson at the University of Michigan to improve the characterization of biomolecular chemical structures using tandem mass spectrometry techniques. The $150,783 award, effective from April 1, 2025 to March 31, 2028, focuses on elucidating the mechanisms underlying electron capture/detachment dissociation...
The National Science Foundation Division of Chemistry awarded a $1,010,000 project grant to the University of Texas at Austin to develop innovative mass spectrometry methods for characterizing intact proteins through June 2025 under the Mathematical and Physical Sciences program (CFDA 47.049). Professor Jenny Brodbelt and her research group will apply ultraviolet photodissociation and other dynamic ion manipulation strategies to amplify structural and post-translational modification details...
The University of Michigan will receive $675,000 under a three-year Project Grant from the National Science Foundation Division of Molecular and Cellular Biosciences. The grant funds research titled "Unveiling Functionally Critical, Ephemeral RNA (Un)folding States with Magnetic Tape Head Tweezers" from December 2021 through November 2024. The research aims to advance understanding of major problems in biological sciences by using magnetic tweezers to study transient unfolding states...
This $597,945 federal Project Grant awarded by the National Science Foundation's (NSF) Division of Chemistry under the Mathematical and Physical Sciences (CFDA 47.049) program supports research by Tobias W. Giessen at the University of Michigan, Ann Arbor to investigate the structure and function of peptide-modifying enzyme filaments found in bacteria and archaea. The proposed work will generate new insights into the self-assembly and catalytic activity of these filamentous enzymes, which...
This $326,557 Project Grant award, funded by the National Science Foundation (NSF) under the Mathematical and Physical Sciences program (CFDA 47.049), supports the development and characterization of novel biomaterials made from folded globular proteins. The award aims to: 1) experimentally characterize the mechanical response of the protein building blocks as a function of force, tethering geometry, and solution environment; 2) directly relate protein domain unfolding to the mechanical response...
This $273,598 CAREER award from the National Science Foundation's (NSF) Mathematical and Physical Sciences Division (CFDA 47.049) to the University of Nevada, Reno seeks to characterize the mechanisms behind gas-phase protein folding. The project aims to develop novel laser-driven activation techniques to assess rapid protein folding pathways using native mass spectrometry. Additionally, the award will support efforts to partner with local tribal secondary schools to increase recruitment and...
This $390,000 National Science Foundation Project Grant, awarded under the Mathematical and Physical Sciences program (CFDA 47.049), will support the development of Absolute Quantitative Protein Footprinting Mass Spectrometry (AQPFMS) for probing protein three-dimensional structures. Professor Hao Chen of the New Jersey Institute of Technology and collaborator Xiaolin Cheng of Ohio State University will refine an approach using AQPFMS to provide quantitative analysis of solvent-accessible...
The National Science Foundation (NSF) Division of Chemistry awarded a $1,500,000 Project Grant to Stanford University under the Mathematical and Physical Sciences (MPS) program (CFDA 47.049). The grant, awarded on March 1, 2024, supports a 3-year research project titled "Evaluating and Advancing Cryo-EM for RNA Conformational Ensembles." The project aims to: (1) design, model, and experimentally probe RNA systems with discrete conformational states, and (2) characterize and challenge...