Project Grant 2555959
- The National Science Foundation Division of Chemistry awarded The Johns Hopkins University a three-year Project Grant totaling $575,000 under the Mathematical and Physical Sciences federal grant program (CFDA 47.049). The grant supports research into the generation and reactivity of biologically relevant reactive sulfur species, including hydroperoxides, and the development of novel photoprecursors and protein persulfidating reagents to produce these species. Professor John P. Toscano of Johns...
- This $249,793 Project Grant awarded by the National Science Foundation's (NSF) Division of Chemistry under the Mathematical and Physical Sciences program supports the development of new ruthenium-based chemical tools to study the biological role of the gaseous signaling molecule hydrogen sulfide (H2S). The research team at the University of California, Santa Barbara aims to leverage the redox and photochemical properties of ruthenium coordination complexes to create H2S-releasing agents that can...
- The National Science Foundation Division of Chemistry awarded $598,188 to the University of Texas at Austin on February 15, 2026, under the Mathematical and Physical Sciences program (CFDA 47.049). The award funds research into enzymatic sulfur incorporation and modification in the biosynthesis of microbial secondary metabolites, directed by Jie Li. The research examines how enzymes transfer, incorporate, and modify sulfur centers in natural products including sulfenic acids and sulfonolipids,...
- The Johns Hopkins University was awarded a $500,000 Project Grant from the National Science Foundation Division of Chemistry to support research involving Lewis base directed intermolecular hydrogen atom transfer. The three-year award, made on September 1, 2021 under the Mathematical and Physical Sciences program (CFDA 47.049), will fund work contributing to the store of scientific knowledge and understanding of major problems in the mathematical and physical sciences. Specifically, the...
- The National Science Foundation Division of Chemistry awarded The Johns Hopkins University $650,000 on August 15, 2026, under the Mathematical and Physical Sciences program to develop new nonheme iron complexes for nitrogen oxide activation and electrocatalysis. Dr. David P. Goldberg and Dr. V. Sara Thoi will investigate iron-based chemical systems designed to convert nitrogen oxide pollutants (NOx) into ammonia through electrochemical processes inspired by natural iron-containing enzymes. The...
- The National Science Foundation Division of Chemistry awarded Brown University $590,767 on July 1, 2026, under the Mathematical and Physical Sciences program (CFDA 47.049) to investigate novel reactions of S-nitrosothiols (RSNO) and develop synthetic methods based on RSNO compounds for advanced manufacturing of heteroatom-containing pharmaceuticals. Professor Ming Xian of Brown's Department of Chemistry leads the research, which examines RSNO as synthons for constructing sulfur-, nitrogen-,...
- The National Science Foundation Division of Chemistry awarded the University of Pennsylvania $600,000 on September 1, 2026, under the Mathematical and Physical Sciences program (CFDA 47.049) to support research on cross-electrophile coupling methods for forming carbon-sulfur bonds led by Professor Patrick J. Walsh. The research develops transition metal-catalyzed processes to generate enantioenriched sulfur-based building blocks—compounds vital in organic synthesis and medicinal chemistry—from...
- The National Institute of General Medical Sciences awarded the University of Oregon $398,464 on March 6, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop responsive and targeted modulation of reactive sulfur species. Over the five-year period of performance ending December 31, 2030, the recipient will develop innovative chemical approaches to manipulate and understand hydrogen sulfide (H2S) and reactive sulfur species (RSS) in biological systems. The...
- Professor Steven Rokita of Johns Hopkins University was awarded a $510,000 Project Grant from the National Science Foundation's Mathematical and Physical Sciences program (CFDA 47.049) to develop new biocatalysts through cofactor engineering. The three-year award running from July 2022 to June 2025 will support research using organic synthesis to create novel cofactors that, paired with protein scaffolds, could enable applications in green chemistry and bioremediation. By modifying cofactors...
- Federal Grant Award Summary The National Science Foundation's Division of Chemistry, under the Mathematical and Physical Sciences program (CFDA 47.049), awarded $325,000 to Johns Hopkins University as part of a collaborative research project titled "Collaborative Research: Leveraging Spatial Constraints to Tailor the Free Energy Landscapes of Heterogenized Molecular Catalysts." The award, effective from August 1, 2025 through July 31, 2028, supports fundamental research conducted...
The National Science Foundation Division of Chemistry awarded The Johns Hopkins University $600,000 on July 15, 2026, under the Mathematical and Physical Sciences program (CFDA 47.049) to develop new precursors and methods for generating biologically relevant reactive sulfur species, including hydropersulfides (RSSH) and sulfilimine (HNS), under the direction of Professor John P. Toscano in the Department of Chemistry. The research addresses the chemical mechanisms underlying hydrogen sulfide (H₂S) signaling in mammalian tissues, with focus on RSSH as a putative endogenous antioxidant system against ferroptosis and oxidative stress-induced peroxidation of membrane phospholipids. Because these reactive sulfur species are highly unstable in aqueous solution, the project will develop novel approaches to their efficient and controlled production and membrane-targeted delivery to enable their study and exploration of potential biological applications. The work includes an integrated afterschool science outreach program for high school students centered on zebrafish, diseases, and drug development, and will provide comprehensive training for graduate and undergraduate students. Performance takes place in Baltimore, Maryland, with a period of performance extending from the award date through June 30, 2029.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $600.0k | 7/16/26 |