Project Grant 2547050
- This National Science Foundation (NSF) Project Grant award, under the Engineering program (CFDA 47.041), provides $279,376 to Washington University to conduct research on the mechanisms of right ventricular (RV) stiffening and its impact on cardiac health. The project aims to delineate and model the intra- and extra-cellular mechanisms contributing to RV myocardial stiffening using a combination of experimental and computational approaches. Specifically, the researchers will perform...
- This Project Grant award from the National Science Foundation's (NSF) Engineering program (CFDA 47.041) provides $373,596 to the University of Texas at Austin to delineate and model the intra- and extra-cellular mechanisms contributing to right ventricular (RV) myocardial stiffening. The research will utilize a combination of experimental and computational approaches, including micro-scale mechanical tests on individual cardiomyocytes and combined cardiomyocyte-extracellular matrix strip...
- Federal Grant Award Summary The University of New Mexico's Office of Sponsored Projects received a $517,390 Faculty Early Career Development (CAREER) award from the National Science Foundation's Division of Civil, Mechanical, and Manufacturing Innovation under the Engineering program (CFDA 47.041), effective October 1, 2025 through July 31, 2027. This project grant supports fundamental research to develop mechanistic understanding of how multiscale biophysical cues—including stiffness,...
- Federal Project Grant Award Summary The University of California, San Diego received a $600,000 project grant from the National Science Foundation (NSF) Division of Chemical, Bioengineering, Environmental, and Transport Systems under the Engineering program (CFDA 47.041), effective May 1, 2025, through April 30, 2030. This CAREER award funds a comprehensive research initiative investigating X-chromosome inactivation dynamics in myofibroblasts using engineered hydrogels to understand sex-specific...
- Federal Grant Award Summary San Diego State University Research Foundation received a $376,176 Project Grant from the National Science Foundation's Division of Civil, Mechanical, and Manufacturing Innovation (Engineering program, CFDA 47.041) beginning August 1, 2025, and concluding July 31, 2028. The award supports collaborative research investigating plastic deformation and failure mechanisms in elastomeric polymers under ultra-high strain-rate loading conditions. Primary deliverables...
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded a $231,552 Project Grant to the University of California, San Diego on September 16, 2025, under the Cardiovascular Diseases Research program (CFDA 93.837). This research project, titled "Tissue Elasticity and Viscosity Modulates Macrophage-Fibroblast Signaling in Cardiac Fibrosis," focuses on investigating the mechanisms underlying cardiac fibrosis through the study of interactions between...
- The National Science Foundation awarded a $279,606 Project Grant to the University of California Irvine under the Engineering federal grant program (CFDA 47.041). The grant supports collaborative research to develop multiscale computational models characterizing how heart muscle cells adapt mechanically to changes in load conditions. Through experimental measurement and multi-scale modeling, the university researchers will elucidate the acute functional response and long-term remodeling response...
- This National Science Foundation (NSF) Project Grant award under CFDA 47.041 (Engineering) supports the development of a new computational model to predict the complex interactions between ventricular assist devices (VADs) and the beating native heart. The goal is to create a "digital twin" of an experimental mock circulatory loop used for testing VAD safety and efficacy. This $195,291 award, effective August 1, 2024 through July 31, 2026, will result in a lumped parameter model that...
- The University of California, San Diego was awarded a $551,341 Project Grant from the National Science Foundation's Engineering program (CFDA 47.041) for the period of March 1, 2021 through February 28, 2026. The grant funds research into the mechanical and structural adaptations of blood vessels in pulmonary arterial hypertension. Specifically, the university will examine how blood vessels in the lungs change over time in response to high blood pressure conditions. This work will further the...
- Federal Grant Award Summary Award Overview: Lehigh University received a $300,000 Project Grant from the National Science Foundation (NSF) Engineering program (CFDA 47.041) on February 15, 2026, with a completion date of December 31, 2029. This CAREER (Faculty Early Career Development) award supports research to develop and validate chest surface vibration analysis as a diagnostic screening tool for critical congenital heart defects (CCHDs) in newborns. The project will characterize...
Federal Project Grant Award Summary This collaborative research project grant, awarded by the National Science Foundation's Division of Civil, Mechanical, and Manufacturing Innovation under the Engineering program (CFDA 47.041), provides $115,117 in funding to San Diego State University Research Foundation. The award, obligated on August 15, 2025, with completion targeted for June 30, 2026, supports fundamental research investigating the viscoelastic properties of the right ventricle under acute stress and chronic pulmonary hypertension. The primary deliverable is a comprehensive analysis of right ventricle tissue viscoelasticity through experimental characterization via stress relaxation and cyclical tensile testing combined with validated computational modeling, which will advance understanding of how cardiac tissue mechanical behavior impacts organ function in disease conditions. The research outputs generated through this funding are designed to inform clinical care strategies for approximately 6.7 million heart failure patients, while simultaneously addressing workforce development objectives. The project incorporates an educational component focused on advancing bioengineering education and enhancing diversity in the Science, Technology, Engineering, and Mathematics (STEM) workforce through mentoring of women and first-generation students. Deliverables include experimental data on tissue biaxial viscoelasticity characteristics at varied heart rates and disease progression stages, computational models validating these properties, and cellular-level mechanistic insights into how microtubule and extracellular components contribute to overall tissue viscoelasticity.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $115.1k | 9/18/25 |