Project Grant 2545233
- Federal Grant Award Summary This $1,998,147 project grant, awarded by the National Science Foundation (NSF) Directorate for Engineering under the Engineering program (CFDA 47.041) on August 15, 2025, supports the development of an innovative biocomputing platform at Rice University. The research will create engineered bacterial consortia capable of performing parallel biological computing through integrated chemical and electronic signaling networks. The primary deliverable is the...
- Federal Grant Award Summary The National Science Foundation (NSF) Division of Electrical, Communications and Cyber Systems awarded $200,000 to the University of Massachusetts on June 15, 2025, under the Engineering program (CFDA 47.041) for a project titled "Closed-Loop Hybrid Intelligence with Optogenetic-Neuromorphic Co-Designed Cell Interfaces." The project, scheduled for completion by May 31, 2028, delivers advanced engineering tools and methods that integrate high-resolution...
- Federal Grant Award Summary The University of Chicago received a $300,000 Project Grant from the National Science Foundation (NSF) Division of Chemical, Bioengineering, Environmental, and Transport Systems under the Engineering program (CFDA 47.041), effective October 1, 2025, through September 30, 2027. The award funds research to develop a novel class of dynamic molecules based on intrinsically disordered proteins (IDPs) that can sense environmental cues and trigger rapid, gated cellular...
- Federal Project Grant Award Summary Iowa State University of Science and Technology received a $450,000 project grant from the National Science Foundation's Engineering program (CFDA 47.041) awarded June 1, 2025, with completion scheduled for May 31, 2028. The award funds development of In Vitro Biomanufacturing on a Chip (IBOC), an advanced microfluidic platform designed to accelerate bioproduct development and commercialization. The IBOC system integrates nanophotonic sensors—specifically a...
- Summary This $450,000 Project Grant from the National Science Foundation (NSF) Engineering program (CFDA 47.041), awarded to Texas Tech University System on September 1, 2025, supports collaborative research to develop self-regulating artificial cilia arrays capable of precise, omnidirectional fluid and particle manipulation at the microscale. The project, scheduled for completion by August 31, 2028, will deliver soft filament arrays that autonomously adjust their motor patterns in response to...
- Federal Grant Award Summary Iowa State University of Science and Technology received a $552,957 Project Grant award from the National Science Foundation (NSF) Engineering program (CFDA 47.041), effective October 15, 2025, with a completion date of September 30, 2028. The award funds the development of a chip-based in vitro platform designed to study interactions between gut microbiota and brain tissue models through an artificial blood-brain barrier (BBB). This reductionist research model will...
- Federal Project Grant Award Summary The National Science Foundation (NSF) Engineering program (CFDA 47.041) awarded $600,000 to the University of Illinois, effective September 1, 2025, through August 31, 2030. This CAREER award supports research focused on developing methods to optically reprogram and replicate neural circuits in zebrafish larvae as a model system for understanding and treating brain disorders. The core deliverable involves demonstrating signal transfer from healthy brains to...
- Federal Grant Award Summary The National Science Foundation's Division of Information and Intelligent Systems awarded a $299,998 Project Grant to the University of Nebraska (Board of Regents) under the Computer and Information Science and Engineering program (CFDA 47.070) effective September 1, 2025, through February 28, 2027. This Exploratory (EAGER) research initiative seeks to develop a bio-hybrid computing system leveraging bacterial gene regulatory artificial neural networks (GR-ANN) for...
- Federal Grant Award Summary The University of Illinois received a $300,000 Project Grant from the National Science Foundation (NSF) Division of Civil, Mechanical, and Manufacturing Innovation under the Engineering program (CFDA 47.041) to conduct collaborative research on the foundations of super-linearization. Awarded August 1, 2025, with completion targeted for July 31, 2028, this three-year initiative delivers research products and services focused on transforming nonlinear dynamical...
- Federal Grant Award Summary The National Science Foundation's Directorate for Engineering (CFDA 47.041) awarded University of California, Irvine $210,000 for an Exploratory research (EAGER) project beginning May 1, 2026 and concluding April 30, 2028. The project develops an Enzymatic Perturbation Specificity Test (EPST), a built-in validation mechanism for wearable and point-of-care biosensors that operate in interstitial fluid beneath the skin. EPST addresses a critical gap in current biosensor...
The National Science Foundation (NSF) Directorate for Engineering awarded $400,000 to Illinois Institute of Technology's Sponsored Research and Programs Division on September 1, 2026, under the Engineering program (CFDA 47.041) to develop a generalizable "organ-on-a-controller" platform for adaptive control of complex biological systems. The project, with a completion date of August 31, 2029, will create an integrated system combining multiplexed biosensors, predictive computational modeling, and closed-loop adaptive control mechanisms to monitor and regulate the health and function of human hepatocytes in microfluidic devices. The system will integrate real-time monitoring of vital cellular indicators such as protein production and metabolite levels, machine learning models that predict cellular responses to drugs and nutrients, and intelligent control algorithms that automatically adjust cellular inputs to achieve or maintain desired health states and guide diseased cells back to normal function. This closed-loop control platform addresses a fundamental gap in current open-loop organ-on-chip microphysiological systems by enabling dynamic regulation of cellular function based on real-time feedback. The resulting technology is designed to accelerate drug discovery, advance personalized medicine, reduce reliance on animal testing, and deepen understanding of chronic diseases such as fatty liver disease. The award supports fundamental engineering research aligned with NSF's mission to foster innovation and excellence, with potential applications spanning biotechnology and advanced biomanufacturing sectors.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $400.0k | 1/29/26 |