Federal Project Grant Award Summary

The National Science Foundation (NSF), Division of Materials Research, awarded a CAREER grant under the Mathematical and Physical Sciences program (CFDA 47.049) to the University of Texas at Austin for $422,993 beginning July 1, 2026 and concluding June 30, 2031. This five-year project investigates how protein topology and connectivity—specifically ring-shaped and branched protein architectures—influences protein phase separation and biomolecular condensate behavior. Rather than relying solely on sequence-based modifications, the research leverages protein topology as a novel design strategy to engineer programmable biomaterials with tunable, dynamic properties. The project generates fundamental scientific knowledge advancing understanding of biomaterial self-organization while producing new methodologies for creating adaptable, functional biomaterials applicable to biotechnology and bioengineering sectors.

Beyond research deliverables, the award supports an integrated education and outreach program training graduate and undergraduate students in advanced biotechnology, materials science, and artificial intelligence-driven data modeling. The project includes structured K-12 outreach activities featuring hands-on demonstrations and community engagement to increase public understanding of biotechnology and materials science. Collectively, the research and educational components address an understudied area in biomaterials science while building workforce capacity in emerging biotechnology disciplines through academic and public engagement initiatives.