Project Grant 2542672
- This $200,000 Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences program (CFDA 47.049) supports a collaborative research effort led by New York University (NYU) School of Medicine. The project aims to enhance the design of fluorinated protein fibers and hydrogels for medical applications. Key objectives include: 1) generating coiled-coil fluorinated fibers for controlled drug delivery, 2) developing temperature-responsive fluorinated hydrogels,...
- Federal Grant Award Summary The National Science Foundation's Division of Materials Research awarded a five-year CAREER grant totaling $307,515 to the Colorado School of Mines, beginning March 1, 2025. This project grant supports research into polymer-mediated delivery of genome-editing proteins through statistical learning and interfacial engineering. The primary deliverable is the development of innovative computational and experimental methods to identify optimal polymer designs for...
- This Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences program (CFDA 47.049) provides $300,000 to New York University (NYU) to enhance the design of fluorinated protein fibers and hydrogels for medical applications. The key objectives are: 1) generating coiled-coil fluorinated fibers for controlled drug delivery, 2) developing fluorinated coiled-coil hydrogels that change with temperature, and 3) assessing the potential of these materials as...
- This Project Grant award from the National Science Foundation's Engineering program (CFDA 47.041) will provide $646,451.00 to The Regents of the University of Colorado over a 5-year period from June 1, 2025 to May 31, 2030. The project, titled "CAREER: Defining How Extracellular Matrix Mechanics Regulate Neutrophil Function", will conduct research to understand how a tissue's mechanical properties influence the function of neutrophils, a key immune cell type. The research aims to...
- This $475,670 CAREER Project Grant awarded by the National Science Foundation's Division of Chemical, Bioengineering, Environmental, and Transport Systems (CFDA 47.041) aims to develop a new method for tracking molecular changes in live tissue over time. The project will focus on creating a nanostructure-based system to continuously monitor cellular activity and interactions, which can help improve understanding of cellular behavior and advance medical treatments, particularly for complex...
- The National Science Foundation (NSF) awarded a 4-year, $400,000 Project Grant under the Mathematical and Physical Sciences program (CFDA 47.049) to Trustees of Boston University for their research project titled "COLLABORATIVE RESEARCH: DMREF: CLOSED-LOOP DESIGN OF POLYMERS WITH ADAPTIVE NETWORKS FOR EXTREME MECHANICS." The project aims to develop an integrated experimental and computational platform for accelerated discovery and design of novel polymers exhibiting unprecedented...
- The National Science Foundation (NSF) awarded Arizona State University, through its Division of Materials Research, a $318,694 CAREER grant under the Mathematical and Physical Sciences (CFDA 47.049) program. The purpose of this 26-month project is to develop strategies to incorporate responsive, pore-forming structures into polymeric vesicles, aiming to create cell-like materials that can respond to mechanical, optical, and pH stimuli. The research seeks to advance the understanding of...
- This $235,977 Project Grant awarded by the National Science Foundation (NSF) under the Integrative Activities program (CFDA 47.083) will support a collaboration between the University of Maine (UMaine) and the Molecular Foundry at Lawrence Berkeley National Laboratory to develop a new class of biomimetic hydrogel materials for tissue engineering and stem cell therapy applications. The key objectives are to: 1) synthesize a library of functionalized peptoid conjugates capable of forming...
- This $476,886 federal Project Grant award from the National Science Foundation (NSF) Engineering program (CFDA 47.041) supports research at Boston University to develop computational models for predicting the spatiotemporal distribution of growth factors in tissue engineering scaffolds. The goal is to optimize scaffold designs to achieve optimal growth factor exposure profiles that improve tissue regeneration outcomes, particularly for cartilage repair. The research utilizes reaction-diffusion...
- The National Science Foundation Division of Materials Research awarded Tufts University a $525,000 Project Grant under the Mathematical and Physical Sciences program (CFDA 47.049) to support research titled "DYNAMIC PROTEIN-BASED BIOMATERIAL DESIGNS FOR BIONIC COATINGS" from June 15, 2021 through May 31, 2024. The grant funds research into developing dynamic protein-based biomaterial designs that can be used for bionic coatings. The Mathematical and Physical Sciences program aims to...
This CAREER (Faculty Early Career Development) project grant awards $524,997 to Trustees of Boston University, funded by the Division of Materials Research under the Mathematical and Physical Sciences program (CFDA 47.049). The award, effective February 15, 2026, through January 31, 2031, supports the development of hybrid metal-organic framework-hydrogel biomaterials designed to create bio-instructive chemokine gradients. The research delivers computational modeling-informed design and development of rationally structured combinations of porous nanoparticles with hydrogel chemistry that can encapsulate, protect, and release chemical signals to guide immune cell behavior in three-dimensional environments. Key deliverables include establishing structure-function relationships that define how nanoparticle design features—including pore size, degradation rate, and chemical interactions—control chemokine protection and gradient formation, thereby advancing biotechnology applications in immunological research. This fundamental research initiative represents a significant departure from conventional hydrogel platforms that function as passive reservoirs with limited signal release capabilities. By uncovering how hybrid biomaterial design parameters influence chemokine behavior, the project aims to provide researchers with innovative tools to precisely program complex biological signaling patterns that better mimic the body's natural cell-guidance mechanisms, with potential applications in infection response, immune regulation, and regenerative medicine.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $525.0k | 2/11/26 |